IP(3) receptors: toward understanding their activation.

  title={IP(3) receptors: toward understanding their activation.},
  author={Colin W Taylor and Stephen C. Tovey},
  journal={Cold Spring Harbor perspectives in biology},
  volume={2 12},
Inositol 1,4,5-trisphosphate receptors (IP(3)R) and their relatives, ryanodine receptors, are the channels that most often mediate Ca(2+) release from intracellular stores. Their regulation by Ca(2+) allows them also to propagate cytosolic Ca(2+) signals regeneratively. This brief review addresses the structural basis of IP(3)R activation by IP(3) and Ca(2+). IP(3) initiates IP(3)R activation by promoting Ca(2+) binding to a stimulatory Ca(2+)-binding site, the identity of which is unresolved… CONTINUE READING


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