INVESTIGATIVE REPORT Expression of p21, p53, bcl-2 and Ki-67 in Venous Leg Ulcers with and without Squamous Cell Carcinoma


In order to gain understanding of the cellular mechanisms of malignant transformation in chronic venous leg ulcers, we analysed by immunohistochemistry the presence of p21, p53, bcl-2 and Ki-67 in ulcers with and without squamous cell carcinoma. The material consisted of 41 archived histopathological samples from 33 patients with chronic venous leg ulcers… (More)


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