Corpus ID: 2436643

INTRODUCTION Systems biology is computational and mathematical modeling of a complex biological Computational systems biology in cancer brain metastasis

  title={INTRODUCTION Systems biology is computational and mathematical modeling of a complex biological Computational systems biology in cancer brain metastasis},
  author={Huiming Peng and Hua Tan and Weiling Zhao and G. Jin and Sambad Sharma and F. Xing and K. Watabe and Xiaobo Zhou},
Brain metastases occur in 20-40% of patients with advanced malignancies. A better understanding of the mechanism of this disease will help us to identify novel therapeutic strategies. In this review, we will discuss the systems biology approaches used in this area, including bioinformatics and mathematical modeling. Bioinformatics has been used for identifying the molecular mechanisms driving brain metastasis and mathematical modeling methods for analyzing dynamics of a system and predicting… Expand

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