INTRAVITREAL CLINDAMYCIN FOR TOXOPLASMIC RETINOCHOROIDITIS

@article{Sobrin2007INTRAVITREALCF,
  title={INTRAVITREAL CLINDAMYCIN FOR TOXOPLASMIC RETINOCHOROIDITIS},
  author={Lucia Sobrin and Leila I. Kump and Christopher S Foster},
  journal={Retina},
  year={2007},
  volume={27},
  pages={952-957}
}
Purpose: To report outcomes of off-label use of intravitreal clindamycin in the treatment of toxoplasmic retinochoroiditis. Methods: In a noncomparative, retrospective, interventional case series, we reviewed the charts of six consecutive patients with toxoplasmic retinochoroiditis who were treated with intravitreal injection of clindamycin (1.0 mg/0.1 mL) because of intolerance to or disease progression despite oral microbial treatment. The primary outcome measures were change in Snellen… 
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Local treatment of toxoplasmic retinochoroiditis with intravitreal clindamycin and dexamethasone.
TLDR
Local treatment with intravitreal injections of clindamycin and dexamethasone without concomitant systemic therapy was associated with resolution of TRC in patients without macular or juxtapapillary involvement.
Intravitreal clindamycin and dexamethasone for zone 1 toxoplasmic retinochoroiditis at twenty-four months.
Intravitreal Clindamycin as First-Line Therapy for Toxoplasmic Retinochoroiditis: A Case Series
TLDR
Intravitreal clindamycin, combined with oral corticosteroids, can be considered an effective and safe first-line therapy for active toxoplasmic retinochoroiditis and provides the patient a more convenience, safer systemic side effect profile, increased availability, and fewer follow-up visits and hematologic investigations.
Intravitreal Clindamycin in the Treatment of Unresponsive Zone One Toxoplasmic Chorioretinitis: A Case Report
TLDR
Intravitreal injection of clindamycin may be an acceptable alternative to the classic treatment in cases with refractory ocular toxoplasmosis and would be helpful in caseswith involvement of macula or closeness to the optic nerve.
Intravitreal Clindamycin and Dexamethasone Combined with Systemic Oral Antitoxoplasma Therapy versus Intravitreal Therapy Alone in the Management of Toxoplasma Retinochoroiditis: A Retrospective Study
TLDR
IVCD is an effective route of treatment for active toxoplasmic retinochoroiditis that can be used solely without the need to use systemic medications.
Randomized trial of intravitreal clindamycin and dexamethasone versus pyrimethamine, sulfadiazine, and prednisolone in treatment of ocular toxoplasmosis.
Current Treatment of Toxoplasma Retinochoroiditis: An Evidence-Based Review
TLDR
There was conflicting evidence as to the effectiveness of systemic antibiotics for TRC and there is no evidence to support that one antibiotic regimen is superior to another so choice needs to be informed by the safety profile.
Intravitreal clindamycin plus dexamethasone versus classic oral therapy in toxoplasmic retinochoroiditis: a prospective randomized clinical trial
TLDR
In conclusion, both IVCD and COT are equally effective against active toxoplasmic retinochoroiditis but the former is apparently safer and more convenient.
Safety of intravitreal clindamycin in albino rabbit eyes
TLDR
Intravitreal injection of 1 mg clindamycin does not cause functional or morphological signs of retinal toxicity in albino rabbits, during a period of 4 weeks post-injection.
Successful treatment of toxoplasmosis-associated choroidal neovascular lesions with bevacizumab and antiparasitic therapy.
TLDR
Oral trimethoprim/sulfamethoxazole is an effective and less expensive antibiotic against Toxoplasma gondii and intravitreal bevacizumab injection appears to be a well-tolerated treatment for toxoplasmosis-associated CNV and has the potential as an adjuvant therapy to improve final vision.
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References

SHOWING 1-10 OF 20 REFERENCES
Intravitreal clindamycin and dexamethasone for toxoplasmic retinochoroiditis.
TLDR
Intravitreal injections of clindamycin and dexamethasone are well tolerated and may offer an additional strategy to treat TRC in patients who are unable to afford or tolerate systemic therapy, or whose disease progresses despite systemic therapy.
Atypical, severe toxoplasmic retinochoroiditis in elderly patients.
Quadruple therapy for ocular toxoplasmosis.
  • S. Lam, H. Tessler
  • Medicine
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • 1993
TLDR
Between Dec. 1, 1973, and May 30, 1989, 36 patients with ocular toxoplasmosis seen at a uveitis clinic received quadruple therapy (pyrimethamine, trisulfapyrimidines, clindamycin and prednisone), with all but four of the cases showed improved vision.
Current practices in the management of ocular toxoplasmosis.
Results of treatment of ocular toxoplasmosis with injectable corticosteroids.
  • R. Nozik
  • Medicine
    Transactions. Section on Ophthalmology. American Academy of Ophthalmology and Otolaryngology
  • 1977
TLDR
The study did not reveal any reliable way of predicting which patients would be good risks for the use of periocular injections of depot corticosteroids, and it does suggest that the concurrent use of antitoxoplasma agents might protect patients in such a way thatperiocular depot cortiosteroids would not worsen their disease.
Therapy of ocular toxoplasmosis
TLDR
The most frequent side effects were also associated with pyrimethamine medication and included hematologic complications as thrombocytopenia and leucopenia despite leucovorin medication.
Prospective randomized trial of trimethoprim/sulfamethoxazole versus pyrimethamine and sulfadiazine in the treatment of ocular toxoplasmosis.
Clindamycin in the treatment of human ocular toxoplasmosis.
  • G. Tate, R. Martin
  • Medicine
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • 1977
Clindamycin was used systemically and periocularly to treat six patients with ocular toxoplasmosis who had a total of eight attacks. Although it appeared to quiet the attack promptly, several side…
Intravitreal drug therapy.
TLDR
The anti-inflammatory action of dexamethasone and cyclosporine A is evaluated to reduce intraocular inflammation after intraocular surgery or in uveitis and the role of vitrectomy in the treatment of bacterial fungal endophthalmitis is defined.
Successful management of ocular toxoplasmosis during pregnancy using combined intraocular clindamycin and dexamethasone with systemic sulfadiazine
TLDR
There is a need to develop new, effective ways to treat toxoplasmosis retinitis while minimizing fetal exposure to multiple drugs (with theoretical teratogenicity), and decreasing the chances of fetal transmission.
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