• Corpus ID: 212453368

INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES

@inproceedings{Dashora2014INTERNATIONALJO,
  title={INTERNATIONAL JOURNAL OF PHARMACY \& LIFE SCIENCES},
  author={Alankrita Dashora and Kanika Sharma},
  year={2014}
}

• A. Dashora, K. Sharma
• Published 2014
• Medicine

Peptic ulcer is an excoriated area of the gastric or duodenal mucosa caused by action of the gastric juice. It is a chronic, recurrent and the most predominant disease of the gastrointestinal (GI) diseases, which is generally caused by a lack of equilibrium between the gastric aggressive factors and the mucosal defensive factors. Many indigenous Indian medicinal plants have been found to successfully manage GI diseases. In the present study Caralluma attenuata (C. attenuata) locally known as ‘Kundaetikommu’ was studied in the treatment of antiulcer activity with the help of different ulcer models in rats. Rat was sacrificed and stomach was removed for observation of ulcer scores, ulcer index, free acidity, total acidity and pH. The C. attenuata maintains the integrity of gastric mucosa by virtue of its effect on offensive and defensive gastric mucosal factors. C. attenuata significantly (P<0.05) decreased free acidity, total acidity, ulcer index and gastric volume and significantly (P<0.05) increased the pH whereas ulcer index significantly (P<0.05) decreased in all the ulcer models in rats. Current study shows that C. attenuata has the potential to be used as an antiulcer. Key-Words: Gastric ulcer, Peptic ulcer, Antiulcer, Ulcer index, Caralluma attenuata Introduction Gastric ulcer is among the most serious diseases in the world. The goals of treating peptic ulcer disease are to relieve pain, heal the ulcer and prevent ulcer recurrence. A large number of spices and herbs have been evaluated by various researchers for their antiulcer effects to achieve a favorable outcome. Traditional medicinal practitioners have claimed for centuries that extracts from plant (Caralluma attenuata [C. attenuata]) can be effectively used for the evaluation of different type of ulcers. Despite being one of the well-known medicinal plants used in Indian traditional medicine to treat several ailments, studies pertaining to the pharmacological properties of some medicinal plants are very scarce. C .attenuata (Family: Asclepiadaceae) is a thick, succulent perennial herb growing wild in dry hill slope regions of Hyderabad and in several districts of Andhra Pradesh, India. Locally it is known as ‘Kundaetikommu’, and is eaten raw as a cure for diabetes (personal information from users) and the juice of the plant along with black pepper is recommended in the treatment of migraine (Srinivasacharyulu, 1931). * Corresponding Author E-mail: [e-mail] This plant was found to be a rich source of glycosides (Ramesh et al., 1998). C.attenuata was known for the anti-hyperglycemic activity (Venkatesh et al., 2003). The hypoglycemic effect of whole plant C. attenuata was investigated in both normal and alloxan induced diabetic rats (Jayakar et al., 2004). Recently Pradeep et al. (2013) reported antidiabetogenic and antioxidant effects of C. attenuata extract (CAEt) on streptozotocin-induced diabetes in rats. The present study was undertaken to investigate the ethnopharmacological evaluation of CAEt with a view to provide scientific evidence on modern lines.. Material and Methods Test animals Albino rats (150-175g) were purchased from the animal house of National Laboratory Animal Centre, Lucknow, India. They were maintained in standard environmental conditions and had free access to feed and tap water ad libitum during quarantine period. The animals were kept fasting overnight but allowed free access to the water. All studies were performed in accordance with the guidance for care and use of laboratory animals, as adopted and promulgated by the Research Article [Garg et al., 5(6): June, 2014:3585-3589] CODEN (USA): IJPLCP ISSN: 0976-7126 © Sakun Publishing House (SPH): IJPLS 3586 Institutional Animal Care Committee, CPCSEA, India (Reg. No. IAEC/NBRI/PH/6-6)). Plant materials and preparation of extract Fresh whole plants of C. attenuata were collected from Ghatkesar, Andhra Pradesh, India. The plant material was identified taxonomically and authenticated by taxonomist in National Botanical Research Institute, Lucknow. The shade dried plant materials were crushed, powdered and exhaustively extracted with 10 volumes of 50% ethanol. The extract was filtered, pooled and concentrated on rotavapour (Buchi, USA) and dried in lyophilizer (Laboconco, USA) under reduced pressure. Experimental procedure CAEt in doses of 100 & 250mg/kg and Omeprazole, the reference drug, in the dose of 20 mg/kg were administered orally twice daily for 5 days for ulcer protective studies. Control group of animals received suspension of 1% CMC in distilled water.