• Corpus ID: 26406041

INTERLEUKIN ( IL ) – 10 AND TUMOUR NECROSIS FACTOR – ALPHA ( TNF – α ) PROFILES OF INDIVIDUALS WITH Schistosoma haematobium INFECTION IN EWAN COMMUNITY , EDO STATE , NIGERIA

@inproceedings{Imarenezor2016INTERLEUKINI,
  title={INTERLEUKIN ( IL ) – 10 AND TUMOUR NECROSIS FACTOR – ALPHA ( TNF – $\alpha$ ) PROFILES OF INDIVIDUALS WITH Schistosoma haematobium INFECTION IN EWAN COMMUNITY , EDO STATE , NIGERIA},
  author={E. P. K. Imarenezor and O. P. G. Nmorsi and S. Tovey Brown},
  year={2016}
}

• E. Imarenezor, O. Nmorsi, S. T. Brown
• Published 2016
• Medicine

The researched evaluated the profile of interleuki n (IL)-10 and tumor necrosis factor-alpha (TNFα) of 35 volunteers infected with Schistosoma haematobium in Schistosomiasis endemic communities in Ewan, Ak oko Edo Local Government Area, Edo State, Nigeria. Se rum IL-10 levels were significantly higher in Heavi ly positives than control subjects (P<0.001). The diff erence in serum IL-10 concentrations between Lightl y, Moderately and Heavily infected stages of infection was statistically significant (P<0.001). The level of TNFα for Lightly positive, Moderately positive and Heav ily positive were significantly elevated when compa red with the control subjects at χ2 =6.37, P>0.01; χ2 =22.79, P<0.001, χ2=35.57, P<0.001, respectively. The mean difference in serum TNFα concentrations between this levels of infection wa s statistically significant (P<0.0001). We therefore suggest that the elevated levels of IL-10 and TNFα may implicate these cytokines as mediators of host response to Schistosoma haematobium infection in the locality.