INTEGRATED MICROFLUIDIC SELEX USING FREE SOLUTION ELECTROKINETICS.

@article{Olsen2017INTEGRATEDMS,
  title={INTEGRATED MICROFLUIDIC SELEX USING FREE SOLUTION ELECTROKINETICS.},
  author={Timothy R. Olsen and Claudia Tapia-Alveal and Kyung-Ae Yang and Xin Zhang and Leonardo J. Pereira and Nickolaos Farmakidis and Renjun Pei and Milan N. Stojanovic and Qiao Ming Lin},
  journal={Journal of the Electrochemical Society},
  year={2017},
  volume={164 5},
  pages={
          B3122-B3129
        }
}
Systematic evolution of ligands by exponential enrichment (SELEX) offers a powerful method to isolate affinity oligonucleotides known as aptamers, which can then be used in a wide range of applications from drug delivery to biosensing. However, conventional SELEX methods rely on labor intensive and time consuming benchtop operations. A simplified microfluidic approach is presented which allows integration of the affinity selection and amplification stages of SELEX for the isolation of target… CONTINUE READING