INSULIN SECRETAGOGUE EFFECT OF ROOTS OF RAVENALA MADAGASCARIENSIS SONN. - AN IN VITRO STUDY

@article{PRIYADARSINIS2019INSULINSE,
  title={INSULIN SECRETAGOGUE EFFECT OF ROOTS OF RAVENALA MADAGASCARIENSIS SONN. - AN IN VITRO STUDY},
  author={Sakthi PRIYADARSINI S and Kumar Pr and Abhishek Anand and Devendiran B and Venkat S KADIYAM and Richie PADMANABH ROY},
  journal={Asian Journal of Pharmaceutical and Clinical Research},
  year={2019}
}
Objective: The objective of this study was to establish the cytotoxicity profile and to evaluate the insulin secretagogue effect of ethanolic root extract of Ravenala madagascariensis Sonn. Methods: The cell viability of rat insulinoma 5F (RIN5F) cell lines over the treatment of plant extract was assessed by 3-(4,5-dimethyl-2-thiazolyl)- 2,5-diphenyltetrazolium bromide assay. The insulin-releasing effect was evaluated by insulin secretion assay over RIN5F cell lines by enzyme-linked… 
1 Citations

Figures and Tables from this paper

Antitumor effect of leaves of Ravenala madagascariensis Sonn., in PANC1 and SW1990 pancreatic cell lines
Pancreatic cancer is the seventh leading cause of cancer-related deaths in developed countries with an average survival rate of less than 9%. Up to 80% of the patients with pancreatic cancer are

References

SHOWING 1-10 OF 24 REFERENCES
Insulin-secretagogue activity and cytoprotective role of the traditional antidiabetic plant Scoparia dulcis (Sweet Broomweed).
TLDR
The results revealed the possible therapeutic value of Scoparia dulcis for the better control, management and prevention of diabetes mellitus progression and suggested the glucose lowering effect of SPEt to be associated with potentiation of insulin release from pancreatic islets.
In Vivo and in Vitro Evaluation of Anti Diabetic and Insulin Secretagogue Activities of Capparis zeylanica
TLDR
Oral administration of Capparis zeylanica methanolic extract for 28 days showed a significant reduction in blood glucose levels and enhanced circulating insulin levels in Streptozotocin induced diabetes rats, indicating that CZ fruits have the potential to use in diabetes therapy.
Characterisation of the Insulinotropic Activity of an Aqueous Extract of Gymnema Sylvestre in Mouse β-Cells and Human Islets of Langerhans
TLDR
Examination of the effects of a novel GS extract on insulin secretion from the MIN6 β-cell line and isolated human islets of Langerhans indicates that low concentrations of the GS isolate OSA stimulate insulin secretion in vitro, at least in part as a consequence of Ca2+ influx, without compromising β- cell viability.
Anti-diabetic effects of Caulerpa lentillifera: stimulation of insulin secretion in pancreatic β-cells and enhancement of glucose uptake in adipocytes.
  • B. Sharma, D. Rhyu
  • Chemistry, Medicine
    Asian Pacific journal of tropical biomedicine
  • 2014
TLDR
The results suggest that C. lentillifera could be used as a potential anti-diabetic agent.
In vitro and In vivo antidiabetic activity of the leaves of Ravenala madagascariensis Sonn . , on alloxan induced diabetic rats
Ravenala madagascariensis Sonn., (Strelitziaceae) commonly known as Traveler’s palm has been widely used in traditional system of medicine for diabetes. The n-Hexane, ethylacetate, ethanol and
Aqueous extract of Abutilon indicum Sweet inhibits glucose absorption and stimulates insulin secretion in rodents.
TLDR
The observations suggest that the aqueous extract from the A indicum plant has antidiabetic properties, which inhibited glucose absorption and stimulated insulin secretion, and this was at a faster rate than the use of an antidi diabetic drug, glibenclamide.
Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability.
TLDR
Results confirm the stimulatory effects of G. sylvestre on insulin release, but indicate that GS4 acts by increasing cell permeability, rather than by stimulating exocytosis by regulated pathways, which means the suitability of GS4 as a potential novel treatment for NIDDM can not be assessed by direct measurements of beta-cell function in vitro.
Hypolipidaemic and Renoprotective study on the Ethanolic & Aqueous extracts of leaves of Ravenala madagascariensis Sonn., on alloxan induced diabetic rats
Ravenala madagascariensis Sonn. (Strelitziaceae), known as Visirivazhai in Tamil, has been traditionally used in the treatment of diabetes and kidney stone problems. Our earlier studies proved the
Anti-diabetic effects of Centratherum anthelminticum seeds methanolic fraction on pancreatic cells, β-TC6 and its alleviating role in type 2 diabetic rats.
TLDR
CAMFs demonstrated anti-diabetic potential on β-TC6 cells and type 2 diabetic rat model, plausibly through enhancing glucose uptake and insulin secretion.
Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus
TLDR
It is suggested that Ficus deltoidea has the potential to be developed as future oral antidiabetic agent.
...
1
2
3
...