INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study.

@article{Talbert2009INSIG2SA,
  title={INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study.},
  author={Matthew E. Talbert and Carl D. Langefeld and Julie T. Ziegler and Steven M. Haffner and Jill M Norris and Donald W. Bowden},
  journal={Obesity},
  year={2009},
  volume={17 8},
  pages={1554-62}
}
The genome-wide association study by Herbert et al. identified the INSIG2 single-nucleotide polymorphism (SNP) rs7566605 as contributing to increased BMI in ethnically distinct cohorts. The present study sought to further clarify the matter, by testing whether SNPs of INSIG2 influenced quantitative adiposity or glucose homeostasis traits in Hispanics of the Insulin Resistance Atherosclerosis Family Study (IRASFS). Using a tagging SNP approach, rs7566605 and 31 additional SNPs were genotyped in… CONTINUE READING

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