INK4a-ARF alterations and p53 mutations in hepatocellular carcinomas

Abstract

The INK4a-ARF (CDKN2A)- locus on chromosome 9p21 encodes for two tumour suppressor proteins, p16INK4a and p14ARF, that act as upstream regulators of the Rb-CDK4 and p53 pathways. To study the contribution of each pathway in tumorigenesis of hepatocellular carcinoma (HCC), we analysed the alterations of p14ARF, p16INC4a and p53. After microdissection, DNA of… (More)
DOI: 10.1038/sj.onc.1204902

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