INK4a/ARF: a multifunctional tumor suppressor locus.

  title={INK4a/ARF: a multifunctional tumor suppressor locus.},
  author={Norman E Sharpless},
  journal={Mutation research},
  volume={576 1-2},
The INK4a/ARF locus encodes two physically linked tumor suppressor proteins, p16(INK4a) and ARF, which regulate the RB and p53 pathways, respectively. The unusual genomic relationship of the open reading frames of these proteins initially fueled speculation that only one of the two was the true tumor suppressor, and loss of the other merely coincidental in cancer. Recent human and mouse genetic data, however, have firmly established that both proteins possess significant in vivo tumor… CONTINUE READING
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