INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions.

@article{Cnepa2007INK4PA,
  title={INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions.},
  author={Eduardo T C{\'a}nepa and Mar{\'i}a {\'E}lida Scassa and Julieta Mar{\'i}a Ceruti and Mariela C. Marazita and Abel L. Carcagno and Pablo F. Sirkin and Mar{\'i}a Florencia Ogara},
  journal={IUBMB life},
  year={2007},
  volume={59 7},
  pages={419-26}
}
The cyclin D-Cdk4-6/INK4/Rb/E2F pathway plays a key role in controlling cell growth by integrating multiple mitogenic and antimitogenic stimuli. The members of INK4 family, comprising p16(INK4a), p15(INK4b), p18(INK4c), and p19(INK4d), block the progression of the cell cycle by binding to either Cdk4 or Cdk6 and inhibiting the action of cyclin D. These INK4 proteins share a similar structure dominated by several ankyrin repeats. Although they appear to be structurally redundant and equally… CONTINUE READING
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