INHIBITORY EFFECTS OF ENDOGENOUS l‐ARGININE ANALOGUES ON NITRIC OXIDE SYNTHESIS IN PLATELETS: ROLE IN PLATELET HYPERAGGREGABILITY IN HYPERTENSION

@article{Meirelles2007INHIBITORYEO,
  title={INHIBITORY EFFECTS OF ENDOGENOUS l‐ARGININE ANALOGUES ON NITRIC OXIDE SYNTHESIS IN PLATELETS: ROLE IN PLATELET HYPERAGGREGABILITY IN HYPERTENSION},
  author={L. De Meirelles and A. Mendes-Ribeiro and M. Santoro and M. A. P. Mendes and M. N. S. B. Da Silva and G. Mann and T. Brunini},
  journal={Clinical and Experimental Pharmacology and Physiology},
  year={2007},
  volume={34}
}
1 An increase in plasma concentrations of endogenous l‐arginine analogues, which are inhibitors of nitric oxide (NO) synthesis, may be involved in platelet activation and the increased risk of thrombosis in essential hypertension. Nitric oxide is synthesised in platelets from the amino acid l‐arginine by inducible and constitutive isoforms of NO synthase (NOS), which leads to increased levels of cGMP. 2 In the present study, we investigated basal intraplatelet cGMP levels, platelet aggregation… Expand
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