INHIBITION OF PULMONARY METASTASIS OF MELANOMA B16FO CELLS IN C57BL/6 MICE BY A NUTRIENT MIXTURE CONSISTING OF ASCORBIC ACID, LYSINE, PROLINE, ARGININE, AND GREEN TEA EXTRACT

@article{Roomi2006INHIBITIONOP,
  title={INHIBITION OF PULMONARY METASTASIS OF MELANOMA B16FO CELLS IN C57BL/6 MICE BY A NUTRIENT MIXTURE CONSISTING OF ASCORBIC ACID, LYSINE, PROLINE, ARGININE, AND GREEN TEA EXTRACT},
  author={Mohd Waheed Roomi and Nusrath W. Roomi and Vadim Ivanov and Tatiana Kalinovsky and Aleksandra Niedzwiecki and Matthias Rath},
  journal={Experimental Lung Research},
  year={2006},
  volume={32},
  pages={517 - 530}
}
The authors investigated the effect of a nutrient mixture (NM) on lung metastasis by B16F0 melanoma cells in C57BL/6 female mice. Mice were divided into equal groups (1 to 6) and injected via tail vein with B16F0 cells (groups 1 to 4), B16FO cells pretreated with NM (group 5), or saline (group 6). Groups 1, 3, 4, 5, and 6 were fed the control diet and group 2 the 0.5% NM supplemented diet. Groups 3 and 4 received NM intraperitoneally (IP) and intravenously (IV), respectively. Two weeks later… 
Suppression of growth and hepatic metastasis of murine B16FO melanoma cells by a novel nutrient mixture.
TLDR
To confirm effects in vivo, the effect of NM on murine B16FO melanoma cells in vitro was investigated, including cell proliferation by MTT assay, morphology by hematoxylin and eosin staining and apoptosis using live green caspase detection kit.
Suppression of metastasis of intratesticular inoculation of B16FO melanoma cells by a novel nutrient mixture in male athymic nude mice
TLDR
These results confirm earlier studies and verify the anti-metastatic potential of NM.
(NM) containing ascorbic acid, amino acids and green tea extract on the inhibition of melanoma growth and metastasis using a model of intratesticular inoculation of B16FO cells
Metastasis, commonly to the lung, is the major cause of mortality from testicular cancer. The aim of the present study was to examine the effect of a novel nutrient mixture (NM) containing ascorbic
A nutrient mixture suppresses hepatic metastasis in athymic nude mice injected with murine B16FO melanoma cells
TLDR
Results suggest that NM has potential in suppression of tumor metastasis in athymic nude mice and drastically reduced metastasis to the liver.
Progress of Tumor Growth and Metastasis After Inoculation of B16FO Melanoma Cells in Kidney of Female Nude Mice Is Inhibited by a Novel Nutrient Mixture
TLDR
Results show that the NM is effective in mitigating the growth of tumors in the kidney and metastases to the lung.
In vivo and In vitro effect of a nutrient mixture on human hepatocarcinoma cell line SK-HEP-1.
UNLABELLED Long-term survival of patients with hepatocellular carcinoma (HCC), a common cancer worldwide, remains poor, due to metastasis and recurrence. AIM To investigate the effect of a novel
Inhibition of 7,12-dimethylbenzanthracene-induced skin tumors by a nutrient mixture
The annual incidence of all forms of skin cancer, the most common of all human cancers, is increasing yearly. A unique nutrient mixture (NM) was shown to exhibit anticancer activity in vivo and in
Inhibition of the SK-N-MC human neuroblastoma cell line in vivo and in vitro by a novel nutrient mixture
TLDR
Results suggest that NM may have therapeutic potential in treating neuroblastoma and in vitro, NM induced dose-dependent apoptosis of SK-N-MC cells and Matrigel invasion and cellular apoptosis and morphology.
Chemopreventive effect of a novel nutrient mixture on lung tumorigenesis induced by urethane in male A/J mice.
TLDR
The in vivo effect of dietary supplementation with a nutrient mixture containing lysine, proline, arginine, ascorbic acid, green tea extract, N-acetyl cysteine, selenium, copper and manganese on the development of urethane-induced lung tumors in male A/J mice suggests that nutrient mixture has inhibitory potential.
Chemopreventive Effect of a Novel Nutrient Mixture on Lung Tumorigenesis Induced by Urethane in Male A/J Mice
Aims and background Lung cancer, a leading cause of cancer death, is associated with exposure to inhalation carcinogens, most commonly those found in tobacco smoke. We investigated the in vivo effect
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References

SHOWING 1-10 OF 51 REFERENCES
In vitro and in vivo antitumorigenic activity of a mixture of lysine, proline, ascorbic acid, and green tea extract on human breast cancer lines MDA-MB-231 and MCF-7
TLDR
In vivo inhibitory effect of a nutrient mixture containing lysine, proline, arginine, ascorbic acid, and epigallocatechin gallate on the growth of human cancer xenografts in female athymic nude mice was investigated and significantly inhibited MMP expression, angiogenesis, and invasion in breast cancer cells, in vitro, offering promise for therapeutic use in the treatment of breast cancer.
Inhibitory effect of Boerhaavia diffusa on experimental metastasis by B16F10 melanoma in C57BL/6 mice.
TLDR
Administration of the aqueous methanol extract of B.diffusa was found to be effective in reducing the metastases formation by B16F10 melanoma cells and more over treatment with the extract enhanced the survival of the animals more than double that of untreated control animals.
In vivo antitumor effect of ascorbic acid, lysine, proline and green tea extract on human prostate cancer PC-3 xenografts in nude mice: evaluation of tumor growth and immunohistochemistry.
TLDR
Nutrient supplementation strongly suppressed the growth of tumors without any adverse effects in nude mice, suggesting strong potential as an anticancer agent.
Modulation of N-methyl-N-nitrosourea induced mammary tumors in Sprague–Dawley rats by combination of lysine, proline, arginine, ascorbic acid and green tea extract
TLDR
Findings suggest that the specific formulation of lysine, proline, arginine, ascorbic acid, and green tea extract tested significantly reduces the incidence and growth of MNU-induced mammary tumors, and therefore has strong potential as a useful therapeutic regimen for inhibiting breast cancer development.
Inhibitory effect of a mixture containing ascorbic acid, lysine, proline and green tea extract on critical parameters in angiogenesis.
TLDR
It is suggested that NM is a relatively non-toxic formulation, which inhibits growth, invasion, metastasis, and angiogenesis of tumor cells.
Dietary supplementation with high-selenium soy protein reduces pulmonary metastasis of melanoma cells in mice.
TLDR
The effect of high-selenium (Se) soy protein on pulmonary metastasis of murine B16BL6 melanoma cells was investigated in male C57BL6 mice and it is suggested that Se is responsible for the greater antimetastatic effect of the high-Se ISP.
Cambodian Phellinus linteus inhibits experimental metastasis of melanoma cells in mice via regulation of urokinase type plasminogen activator.
TLDR
Findings indicate that Cambodian Phellinus linteus may inhibit metastasis at least partly via regulation of uPA associated with tumor cell induced platelet aggregation (TCIPA) and also suggest a further study for isolation of active ingredients and the involvement of adhesion molecule signaling pathway.
[Experimental model for treating pulmonary metastatic melanoma using grape-seed extract, red wine and ethanol].
TLDR
Ethanol administration significantly increased pulmonary metastasis while grape-seed extract and red wine led to their reduction, and macroscopic analysis showed that grape- Seed Extract and Red Wine reduced the number of metastatic nodules.
Antitumor effect of a combination of lysine, proline, arginine, ascorbic acid, and green tea extract on pancreatic cancer cell line MIA PaCa-2
TLDR
The results suggest that the formulation of green tea extract, lysine, proline, and ascorbic acid, tested as a promising adjunct to standard treatment of pancreatic cancer, by inhibiting MMP expression and invasion without toxic effects—important parameters in cancer metastasis.
Antitumor effect of nutrient synergy on human osteosarcoma cells U-2OS, MNNG-HOS and Ewing's sarcoma SK-ES.1.
Current treatment of osteosarcoma is associated with poor prognosis, especially due to the increased risk of developing other cancers with chemotherapy. Therefore, new, safe and effective treatment
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