INHIBITION OF HEXOSE AND GLYCEROL UTILIZATION BY 2-DEOXY-D-GLUCOSE IN TRYPANOSOMA GAMBIENSE AND TRYPANOSOMA RHODESIENSE.

@article{Seed1965INHIBITIONOH,
  title={INHIBITION OF HEXOSE AND GLYCEROL UTILIZATION BY 2-DEOXY-D-GLUCOSE IN TRYPANOSOMA GAMBIENSE AND TRYPANOSOMA RHODESIENSE.},
  author={J. Seed and M. A. Baquero and J. Duda},
  journal={Experimental parasitology},
  year={1965},
  volume={16},
  pages={
          363-8
        }
}
  • J. Seed, M. A. Baquero, J. Duda
  • Published 1965
  • Biology, Medicine
  • Experimental parasitology
  • Abstract It was shown that 2-deoxy-d-glucose (D-2-D) inhibited the fermentation of glucose, mannose, fructose, and glycerol by Trypanosoma gambiense . Evidence is presented that shows D-2-D inhibits metabolism at two sites at least within the Embden-Meyerhof-Parnas pathway. The inhibition of both hexose and glycerol utilization by D-2-D was reversed by the addition of glucose; however, inhibition of glycerol utilization was much more sensitive to reversal. A second analogue of glucose… CONTINUE READING
    33 Citations

    Topics from this paper

    The characterization of hexokinase from Trypanosoma rhodesiense and Trypanosoma gambiense.
    • 18
    Effect of 2-deoxy-D-glucose on Herpetomonas samuelpessoai
    • 5
    Specificity of sugar transport in Trypanosoma gambiense.
    • 29
    Carbohydrate transport in Trypanosoma gambiense.
    • 33
    Carbohydrate effects of amino acid transport by Trypanosoma equiperdum.
    • 8

    References

    SHOWING 1-10 OF 11 REFERENCES
    Evidence for hexose transport in acetone-dried yeast.
    • T. Scharff
    • Biology, Medicine
    • Archives of biochemistry and biophysics
    • 1961
    • 13
    METABOLISM OF SCHIZOTRYPANUM CRUZI CHAGAS. II. GALACTOSE UTILIZATION.
    • 14
    A tentative mechanism for the anaerobic transport of glucose, fructose and mannose in yeast.
    • 16
    The chemical composition of trypanosomes. I. Protein, amino acid and sugar analysis.
    • 51
    The catabolism of glucose by strains of Trypanosoma rhodesiense.
    • 93
    • PDF
    Protein measurement with the Folin phenol reagent.
    • 274,877