INHIBITION OF BRAIN GLUTAMATE DECARBOXYLASE BY 2‐KETO‐4‐PENTENOIC ACID, A METABOLITE OF ALLYLGLYCINE 1

@article{Reingold1979INHIBITIONOB,
  title={INHIBITION OF BRAIN GLUTAMATE DECARBOXYLASE BY 2‐KETO‐4‐PENTENOIC ACID, A METABOLITE OF ALLYLGLYCINE 1},
  author={D. F. Reingold and M. Orlowski},
  journal={Journal of Neurochemistry},
  year={1979},
  volume={32}
}
  • D. F. Reingold, M. Orlowski
  • Published 1979
  • Chemistry, Medicine
  • Journal of Neurochemistry
  • Abstract— 2‐Keto‐4‐pentenoic acid, a potent inhibitor of brain glutamate decarboxylase (Orlowskiet al., 1977) was prepared by oxidative deamination of l‐allylglycine with snake venom l‐amino acid oxidase. In the presence of glutamate the keto acid is a competitive inhibitor of the enzyme with respect to glutamate; its Ki is 2.4 ± 10−6m. After preincubation of brain glutamate decarboxylase with 2‐keto‐4‐pentenoic acid in the absence of glutamate, a slow and incomplete reactivation is obtained by… CONTINUE READING
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