ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation.

@article{Hung2009ING4MC,
  title={ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation.},
  author={Tiffany Hung and Olivier Binda and Karen S. Champagne and Alex J. Kuo and Kyle V. Johnson and Howard Y Chang and Matthew D Simon and Tatiana G Kutateladze and Or P Gozani},
  journal={Molecular cell},
  year={2009},
  volume={33 2},
  pages={248-56}
}
Aberrations in chromatin dynamics play a fundamental role in tumorigenesis, yet relatively little is known of the molecular mechanisms linking histone lysine methylation to neoplastic disease. ING4 (Inhibitor of Growth 4) is a native subunit of an HBO1 histone acetyltransferase (HAT) complex and a tumor suppressor protein. Here we show a critical role for specific recognition of histone H3 trimethylated at lysine 4 (H3K4me3) by the ING4 PHD finger in mediating ING4 gene expression and tumor… CONTINUE READING