ING1b decreases cell proliferation through p53-dependent and -independent mechanisms.

@article{Tsang2003ING1bDC,
  title={ING1b decreases cell proliferation through p53-dependent and -independent mechanisms.},
  author={Fan Cheung Tsang and Lai See Po and Ka Man Leung and Anita Ka Ki Lau and W. Y. Siu and Randy Yat Choi Poon},
  journal={FEBS letters},
  year={2003},
  volume={553 3},
  pages={
          277-85
        }
}
ING1b can stimulate cell cycle arrest, repair, senescence, and apoptosis. The actions of ING1b are attributed to its activation of the tumor suppressor p53. Here we investigate the more subtle effects of ING1b on the cell cycle and DNA damage responses in the absence of p53. To this end, we have generated isogenic cell lines that expressed ING1b and p53 either individually or in combination under the control of inducible promoters. A five- to 10-fold induction of ING1b over the endogenous… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 16 CITATIONS

ING1 and ING2: multifaceted tumor suppressor genes

  • Cellular and Molecular Life Sciences
  • 2013
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

LincRNA-p21 acts as a mediator of ING1b-induced apoptosis

  • Cell Death and Disease
  • 2015
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Similar Papers

Loading similar papers…