ING-1, a monoclonal antibody targeting Ep-CAM in patients with advanced adenocarcinomas.

@article{Bono2004ING1AM,
  title={ING-1, a monoclonal antibody targeting Ep-CAM in patients with advanced adenocarcinomas.},
  author={Johann S de Bono and Anthony William Tolcher and Andre Forero and Gertrude F A Vanhove and Chris H M Takimoto and Robert J. Bauer and Lisa A. Hammond and Amita Patnaik and Mark L White and Sui Shen and Muhammad B Khazaeli and Eric K. Rowinsky and Albert F Lobuglio},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 22},
  pages={7555-65}
}
PURPOSE To determine the feasibility of administration, safety, toxicity, immunogenicity, pharmacokinetics, maximum tolerated dose, and biodistribution of ING-1, a high-affinity, Human-Engineered monoclonal antibody (heMAb) to the Mr 40,000 epithelial cell adhesion molecule Ep-CAM, in patients with advanced adenocarcinomas. EXPERIMENTAL DESIGN ING-1 was initially administered to patients as a 1-hour intravenous infusion every 3 weeks. Toxicity and pharmacokinetic data led to the evaluation of… CONTINUE READING

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A patient dosed at 1.0 mg / kg developed acute pancreatitis with severe abdominal pain , nausea , and vomiting .
A patient dosed at 1.0 mg / kg developed acute pancreatitis with severe abdominal pain , nausea , and vomiting .
A patient dosed at 1.0 mg / kg developed acute pancreatitis with severe abdominal pain , nausea , and vomiting .
A patient dosed at 1.0 mg / kg developed acute pancreatitis with severe abdominal pain , nausea , and vomiting .
NauseaNo subtypeVomiting
A patient dosed at 1.0 mg / kg developed acute pancreatitis with severe abdominal pain , nausea , and vomiting .
NauseaNo subtypeVomiting
A patient dosed at 1.0 mg / kg developed acute pancreatitis with severe abdominal pain , nausea , and vomiting .
VomitingNo subtypeNausea
A patient dosed at 1.0 mg / kg developed acute pancreatitis with severe abdominal pain , nausea , and vomiting .
VomitingNo subtypeNausea
A patient dosed at 1.0 mg / kg developed acute pancreatitis with severe abdominal pain , nausea , and vomiting .
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