Medikamente zur intravenösen Narkoseinduktion: Etomidat
- MedicineDer Anaesthesist
While propofol has enjoyed increasing frequency of use over the last three decades and is currently regarded as the gold standard in numerous clinics, thiopental is a noteworthy alternative apart from its elimination kinetics.
The effect of etomidate on adrenal function in critical illness: a systematic review
- MedicineIntensive Care Medicine
There is an increased rate of AI and mortality in critically ill patients who received etomidate and non-etomidate anesthesia, and this results in an increased risk ratio (RR) for AI.
Acute Adrenal Insufficiency After a Single Dose of Etomidate
- Medicine, BiologyJournal of intensive care medicine
Acute adrenal insufficiency should be suspected in intensive care unit patients who have undergone general anesthesia with etomidate induction and present with hypotension refractory to standard vasopressor administration and in patients who may not tolerate wide variance in heart rate or blood pressure.
Adrenal insufficiency in critically ill patients with human immunodeficiency virus
- Medicine, BiologyCritical care medicine
There is a high incidence of adrenal Insufficiency in critically ill HIV-infected patients that varies with the criteria used to diagnose adrenal insufficiency, and the LD-ACTH stimulation test is more sensitive than the high-dose test for diagnosing adrenalinsufficiency.
Adrenocortical endocrine disruption
- Biology, MedicineThe Journal of Steroid Biochemistry and Molecular Biology
Pro/con debate: Is etomidate safe in hemodynamically unstable critically ill patients?
- MedicineCritical Care
This review presents a pro/con case for using etomidate in hemodynamically unstable critically ill patients and provides guidance for alternative induction techniques and when the use of etomidates might be justified despite these concerns.
Secretion of cortisol and aldosterone as a vulnerable target for adrenal endocrine disruption — screening of 30 selected chemicals in the human H295R cell model
- Biology, MedicineJournal of applied toxicology : JAT
It is shown that adrenal steroidogenesis is a vulnerable target for toxic insult and that the H295R assay is a useful in vitro model for screening purposes.
Pharmacological management of severe Cushing’s syndrome: the role of etomidate
- Medicine, BiologyTherapeutic advances in endocrinology and metabolism
The initial development of etomidate as an anesthetic agent, its subsequent development as a treatment for CS, and the recent advances in dosing and drug development that dissociate sedative-hypnotic and adrenostatic drug actions to facilitate CS treatment in non-critical care settings are discussed.
Etomidate and Adrenocortical Suppression: Should We Take the Concerns to Heart?
- MedicineJournal of cardiothoracic and vascular anesthesia