INFLAMMATORY BOWEL DISEASE Development of colonic neoplasia in p53 deficient mice with experimental colitis induced by dextran sulphate sodium

Abstract

Background: Several animal models for human ulcerative colitis (UC) associated neoplasia have been reported. However, most neoplasias developed in these models have morphological and genetic characteristics different from UC associated neoplasia. Aims: To establish a new colitis associated neoplasia model in p53 deficient mice by treatment with dextran… (More)

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