INFLAMMATION AND INFLAMMATORY BOWEL DISEASE Tumour necrosis factor α potentiates ion secretion induced by histamine in a human intestinal epithelial cell line and in mouse colon: involvement of the phospholipase D pathway

Abstract

Background and aims: Patients suffering from inflammatory bowel disease show increased levels of the mast cell products histamine and tumour necrosis factor α (TNF-α). Treating these patients with antibodies against TNF-α diminishes the symptoms of diarrhoea. In this study, the effect of TNF-α on ion secretion induced by the mast cell mediator histamine in… (More)

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