INFERRING PURGING FROM PEDIGREE DATA

@inproceedings{Gulisija2007INFERRINGPF,
  title={INFERRING PURGING FROM PEDIGREE DATA},
  author={D. Gulisija and J. Crow},
  booktitle={Evolution; international journal of organic evolution},
  year={2007}
}
  • D. Gulisija, J. Crow
  • Published in
    Evolution; international…
    2007
  • Biology, Medicine
  • Abstract The harmful effects of inbreeding can be reduced if deleterious recessive alleles were removed (purged) by selection against homozygotes in earlier generations. If only a few generations are involved, purging is due almost entirely to recessive alleles that reduce fitness to near zero. In this case the amount of purging and allele frequency change can be inferred approximately from pedigree data alone and are independent of the allele frequency. We examined pedigrees of 59,778 U.S… CONTINUE READING
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    References

    SHOWING 1-10 OF 21 REFERENCES
    AN ESTIMATE OF THE MUTATIONAL DAMAGE IN MAN FROM DATA ON CONSANGUINEOUS MARRIAGES.
    • N. Morton, J. Crow, H. Muller
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1956
    • 624
    • PDF
    PERSPECTIVE: PURGING THE GENETIC LOAD: A REVIEW OF THE EXPERIMENTAL EVIDENCE
    • 317
    • PDF
    Ancestral inbreeding only minimally affects inbreeding depression in mammalian populations.
    • J. Ballou
    • Biology, Medicine
    • The Journal of heredity
    • 1997
    • 186
    • PDF
    Coefficients of Inbreeding and Relationship
    • 1,674
    • PDF
    Introduction to quantitative genetics
    • 9,467
    • PDF
    HIERARCHICAL ANALYSIS OF INBREEDING DEPRESSION IN PEROMYSCUS POLIONOTUS
    • 146