INFERRING PURGING FROM PEDIGREE DATA

@inproceedings{Gulisija2007INFERRINGPF,
  title={INFERRING PURGING FROM PEDIGREE DATA},
  author={Davorka Gulisija and James F. Crow},
  booktitle={Evolution; international journal of organic evolution},
  year={2007}
}
Abstract The harmful effects of inbreeding can be reduced if deleterious recessive alleles were removed (purged) by selection against homozygotes in earlier generations. If only a few generations are involved, purging is due almost entirely to recessive alleles that reduce fitness to near zero. In this case the amount of purging and allele frequency change can be inferred approximately from pedigree data alone and are independent of the allele frequency. We examined pedigrees of 59,778 U.S… Expand
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