INDI: a computational framework for inferring drug interactions and their associated recommendations

@inproceedings{Gottlieb2012INDIAC,
  title={INDI: a computational framework for inferring drug interactions and their associated recommendations},
  author={Assaf Gottlieb and Gideon Y. Stein and Y Oron and Eytan Ruppin and Roded Sharan},
  booktitle={Molecular systems biology},
  year={2012}
}
Inferring drug-drug interactions (DDIs) is an essential step in drug development and drug administration. Most computational inference methods focus on modeling drug pharmacokinetics, aiming at interactions that result from a common metabolizing enzyme (CYP). Here, we introduce a novel prediction method, INDI (INferring Drug Interactions), allowing the inference of both pharmacokinetic, CYP-related DDIs (along with their associated CYPs) and pharmacodynamic, non-CYP associated ones. On cross… CONTINUE READING
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