INCREASED INTESTINAL ELIMINATION OF N'-METHYLNICOTINAMIDE IN IRRADIATED RATS.

@article{Detrick1963INCREASEDIE,
  title={INCREASED INTESTINAL ELIMINATION OF N'-METHYLNICOTINAMIDE IN IRRADIATED RATS.},
  author={Lawrence E. Detrick and H. C. Upham and R Springsteen and Thomas J. Haley},
  journal={International journal of radiation biology and related studies in physics, chemistry, and medicine},
  year={1963},
  volume={7},
  pages={
          161-6
        }
}
  • L. Detrick, H. C. Upham, T. Haley
  • Published 1963
  • Biology, Medicine
  • International journal of radiation biology and related studies in physics, chemistry, and medicine
SummaryThe influence of 525 r whole-body x-irradiation on the intestinal absorption and elimination of N′-methylnicotinamide has been investigated. This material does not appear to be absorbed to any appreciable extent by the irradiated animal. A significant increase in elimination of this metabolite via the intestinal tract was found after irradiation, and the increase was maintained even when histological evidence of tissue repair was observed. The greatest increases in elimination were seen… 
3 Citations
Radiation and the detoxication of chemicals.
TLDR
The detoxication of benzoate and resorcinol has been investigated in irradiated animals and detoxication was inhibited from the third to the seventh post-irradiation days, suggesting co-enzyme A and/or its substrates may be responsible.

References

SHOWING 1-6 OF 6 REFERENCES
Synthesis of N'-methylnicotinamide in x-irradiated rats.
  • M. NerurkarM. Sahasrabudhe
  • Biology
    International journal of radiation biology and related studies in physics, chemistry, and medicine
  • 1960
TLDR
Evidence presented seems to indicate that in addition to the radiochemical degradation of methionine, the influence of x-irradiation on the formation and excretion of N'-methylnicotinamide (N'-MeNA) has been investigated and is probably due to impairment of the enzymes involved in this methylation process.
The fluorimetric estimation of N1-methylnicotinamide and its differentiation from coenzyme.
TLDR
Studies of the optimum conditions for the production of fluorescence of some Nl-substituted pyridine compounds, using methyl ethyl ketone instead of acetone, and employing different blanks are dealt with.