INCREASED INOSINATE DEHYDROGENASE ACTIVITY IN MYOPHENOLIC ACID RESISTANT NEUROBLASTOMA CELLS: 88

@article{Hodges1985INCREASEDID,
  title={INCREASED INOSINATE DEHYDROGENASE ACTIVITY IN MYOPHENOLIC ACID RESISTANT NEUROBLASTOMA CELLS: 88},
  author={S. Hodges and Sharon I O'brien and C. C. Lin and F. Snyder},
  journal={Pediatric Research},
  year={1985},
  volume={19},
  pages={758-758}
}
  • S. Hodges, Sharon I O'brien, +1 author F. Snyder
  • Published 1985
  • Chemistry, Medicine
  • Pediatric Research
  • Mouse neuroblastoma cells, NB, have been grown in increasing concentrations of mycophenolic acid for greater than 80 passages. A mycophenolic acid resistant neuroblastoma cell line (NB-MyR) has been isolated which is 1000-fold more resistant to mycophenolic acid than NB cells. Fifty percent growth inhibition was caused by 1.6 × 10−7 M and 1.65 × 10−4 M mycophenolic acid for NB and NB-MyR cells respectively. In crude cell lysates the apparant inhibition constant for mycophenolic acid with… CONTINUE READING

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