IN VIVO AND IN VITRO ANTITUMOR EFFECT OF A UNIQUE NUTRIENT MIXTURE ON LUNG CANCER CELL LINE A-549

@article{WaheedRoomi2006INVA,
  title={IN VIVO AND IN VITRO ANTITUMOR EFFECT OF A UNIQUE NUTRIENT MIXTURE ON LUNG CANCER CELL LINE A-549},
  author={M. Waheed Roomi and Vadim Ivanov and Tatiana Kalinovsky and Aleksandra Niedzwiecki and Matthias Rath},
  journal={Experimental Lung Research},
  year={2006},
  volume={32},
  pages={441 - 453}
}
The high incidence of lung cancer and ineffective toxic action of current mono and doublet chemotherapy approaches result in poor patient survival. Further, matrix metalloproteinases (MMPs) are implicated in neoplastic invasion and metastasis. Based on this, the authors investigated the effect of a dietary micronutrient mixture (NM) containing lysine, proline, arginine, ascorbic acid, and green tea extract on the tumor growth of human lung carcinoma cell A-549 xenografts in athymic nude mice… 
View on Taylor & Francis
www4.dr-rath-foundation.org
21 Citations
Background Citations
7

21 Citations

Citation Type

Citation Type

Modulation of u-PA, MMPs and their inhibitors by a novel nutrient mixture in human lung cancer and mesothelioma cell lines
TLDR
The study of the effect of a nutrient mixture (NM) on the activity of u-PA, MMPs and TIMPs on human lung and malignant mesothelioma cell lines suggests the therapeutic potential of NM in the treatment of lung and mesotelioma cancers.
Antitumor activity of a polysaccharide from longan seed on lung cancer cell line A549 in vitro and in vivo
TLDR
WLSP had the ability to cause cell cycle arrest in G1 phase, activation of caspases 3 and 9, and cleavage of poly[ADP (ribose)] polymerase (PARP) in A549 cells, and showed that WLSP could suppress the growth of xenograft A549 tumors and induce apoptosis.
Polyphenolics from peach (Prunus persica var. Rich Lady) inhibit tumor growth and metastasis of MDA-MB-435 breast cancer cells in vivo.
Expanding Metabolic Targets in Cancer by Select Combinations of Vitamin C and EGCG with Different Natural Compounds
TLDR
In vitro and in vivo studies have shown that synergy-based interaction of selected micronutrients is effective in controlling key mechanisms of cancer, such as inhibition of cancer cell proliferation, invasion, metastasis, triggering apoptosis, and reducing angiogenesis.
Chemopreventive effect of a novel nutrient mixture on lung tumorigenesis induced by urethane in male A/J mice.
TLDR
The in vivo effect of dietary supplementation with a nutrient mixture containing lysine, proline, arginine, ascorbic acid, green tea extract, N-acetyl cysteine, selenium, copper and manganese on the development of urethane-induced lung tumors in male A/J mice suggests that nutrient mixture has inhibitory potential.
Chemopreventive Effect of a Novel Nutrient Mixture on Lung Tumorigenesis Induced by Urethane in Male A/J Mice
TLDR
It is suggested that nutrient mixture has inhibitory potential on the development of mouse lung tumors induced by urethane, and is associated with exposure to inhalation carcinogens found in tobacco smoke.
Anticancer activity of peach and plum extracts against human breast cancer in vitro and in vivo
TLDR
The objective was to elucidate the molecular mechanisms behind the cancer growth-suppression of the phenolics identified in peach and plum extracts for their chemopreventive potential and to evaluate the tumor growthsuppression in vivo.
Catalyser-21TM, a mineral water derived from leaf soil, inhibits tumor cell invasion and angiogenesis
TLDR
The results suggest that Catalyser-21TM has potential as an anti-tumor agent.
Combined arginine and ascorbic acid treatment induces apoptosis in the hepatoma cell line HA22T/VGH and changes in redox status involving the pentose phosphate pathway and reactive oxygen and nitrogen species.
Cancer and metastasis: prevention and treatment by green tea
TLDR
The effect of green tea and its major polyphenolic compounds on cancer and metastasis against most commonly diagnosed cancer sites is summarized.
...
1
2
3
...

References

SHOWING 1-10 OF 42 REFERENCES
In vivo and in vitro antitumor effect of ascorbic acid, lysine, proline and green tea extract on human melanoma cell line A2058.
BACKGROUND Melanoma, a very serious form of skin cancer, causes the most skin cancer-related deaths, due to metastasis. Structural changes in the extracellular matrix (ECM) are necessary for cell…
Inhibitory effect of a mixture containing ascorbic acid, lysine, proline and green tea extract on critical parameters in angiogenesis.
TLDR
It is suggested that NM is a relatively non-toxic formulation, which inhibits growth, invasion, metastasis, and angiogenesis of tumor cells.
SYNERGISTIC ANTITUMOR EFFECT OF ASCORBIC ACID, LYSINE, PROLINE, AND EPIGALLOCATECHIN GALLATE ON HUMAN FIBROSARCOMA CELLS HT-1080
TLDR
The results suggest that the synergistic effect of lysine, proline, and EGCG, is an effective, yet safe agent for adjunctive therapeutic use in the treatment of fibrosarcoma, by inhibiting cell proliferation, MMP expression, and matrigel invasion.
Antiproliferative and Proapoptotic Effect of Ascorbyl Stearate in Human Pancreatic Cancer Cells: Association with Decreased Expression of Insulin-Like Growth Factor 1 Receptor
TLDR
The results demonstrate the efficacy of Asc-S in inhibing growth of pancreatic cancer cells and warrant additional studies to explore the potential utility of this compound as an alternative and/or adjuvant therapeutic modality for Pancreatic cancer.
Inhibitory Effect of Selenite on Invasion of HT1080 Tumor Cells*
TLDR
Selenium, an essential biological trace element, has been shown to reduce and prevent the incidence of cancer and it is demonstrated that selenite also inhibits the invasion of tumor cells.
Ascorbic acid (vitamin C) improves the antineoplastic activity of doxorubicin, cisplatin, and paclitaxel in human breast carcinoma cells in vitro.
The Role of the Thiol N-Acetylcysteine in the Prevention of Tumor Invasion and Angiogenesis
TLDR
Oral administration of NAC reduces the angiogenic response induced by KS tumor cell products, confirming the ability of N-acetylcysteine to inhibit the invasive activity of endothelial cells in vivo and thereby blocking angiogenesis.
Inhibitory effect of N-acetylcysteine on invasion and MMP-9 production of T24 human bladder cancer cells.
TLDR
NAC limits invasion of T24 human bladder cancer cells by inhibiting the M MP-9 production in addition to a direct inhibition of MMP-9 activity.
Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells.
TLDR
Green tea may protect against cancer by causing cell cycle arrest and inducing apoptosis, and needs to be evaluated in human trials.
Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues.
  • Qi Chen, M. Espey, +5 authors M. Levine
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2005
TLDR
Human pharmacokinetics data indicate that ascorbate at concentrations achieved only by i.v. administration may be a pro-drug for formation of H(2)O(2), and that blood can be a delivery system of the pro- drug to tissues.
...
1
2
3
4
5
...