IN VITRO AND IN VIVO EVALUATION OF THE METABOLISM AND PHARMACOKINETICS OF SEBACOYL DINALBUPHINE

@article{Pao2005INVA,
  title={IN VITRO AND IN VIVO EVALUATION OF THE METABOLISM AND PHARMACOKINETICS OF SEBACOYL DINALBUPHINE},
  author={Li-heng Pao and Cheng Huei Hsiong and Oliver Yoa-Pu Hu and Jhi-Jung Wang and Shung-Tai Ho},
  journal={Drug Metabolism and Disposition},
  year={2005},
  volume={33},
  pages={395 - 402}
}
  • L. Pao, C. Hsiong, S. Ho
  • Published 1 March 2005
  • Biology, Medicine, Chemistry
  • Drug Metabolism and Disposition
A diester prodrug of nalbuphine, sebacoyl dinalbuphine (SDN), and its long-acting formulation are currently being developed to prolong the duration of nalbuphine. A comparative in vitro hydrolysis study was conducted for SDN in rat, rabbit, dog, and human blood. Both SDN and nalbuphine in blood or plasma were measured by high-performance liquid chromatography. The hydrolysis rates of SDN in blood were ranked as follows: rat > rabbit > human > dog. The rapid formation of nalbuphine in the blood… 

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