• Corpus ID: 89085324

IN-VITRO ALPHA-AMYLASE AND ALPHA-GLUCOSIDASE INHIBITION ACTIVITY OF UMBELLIFERONE AND BETA-IONONE ISOLATED FROM CORIANDRUM SATIVUM LINN.

@inproceedings{Rayar2016INVITROAA,
  title={IN-VITRO ALPHA-AMYLASE AND ALPHA-GLUCOSIDASE INHIBITION ACTIVITY OF UMBELLIFERONE AND BETA-IONONE ISOLATED FROM CORIANDRUM SATIVUM LINN.},
  author={Ayyasamy Rayar and Rajamanickam Manivannan},
  year={2016}
}
Aims: The objective of the present study was to provide an In‑Vitro evidence for the potential inhibitory activity of Ethanolic extract, Umbelliferone and β-Ionone on α‑amylase and α‑glucosidase enzymes. Materials and Methods: Differentconcentrations (0.1, 0.2, 0.3, 0.4, and 0.5 mg/ml) of Ethanolic extract, Umbelliferone and BetaIonone were subjected to α-amylase and α-glucosidase inhibitory assay. The absorbance was measuredat 540 and 405 nm using multiplate reader and the percentage of… 
The α-amylase and α-glucosidase inhibitory activities of the dichloromethane extracts and constituents of Ferulago bracteata roots
TLDR
It is demonstrated that among the compounds isolated from CH2Cl2 fraction of F. bracteata roots, coumarins were determined as the main chemical constituents of this fraction, the first report on isolation and characterization of the bioactive compounds from root extracts of Ferulago bractedeata.
IN-VITRO ALPHA-AMYLASE AND ALPHA-GLUCOSIDASE INHIBITION ACTIVITY OF DECALEPIS HAMILTONII WIGHT AND ARN
TLDR
Biologically active polyphenol, D-catechin was isolated from Decalepis hamiltonii and characterized by IR, NMR 13C- NMR and evaluation of its in-vitro α-amylase and α-glucosidase inhibition activities and herbal extracts produced a slightly weak alpha glucosid enzyme inhibition when compared with alpha amylase.
Investigating the antidiabetic potential of Phragmanthera capitata, a mistletoe harvested from rubber tree
ABSTRACT This study was designed to investigate the antidiabetic potentials of Phragmanthera capitata, a mistletoe used in folklore for the management of diabetes in Africa. Extracts of the sample in
Evaluation of antiparasitic, anticancer, antimicrobial and hypoglycemic properties of organic extracts from Panamanian mangrove plants
TLDR
Panamanian mangroves are mainly a promising potential source of hypoglycemic compounds, specifically α-glucosidase inhibitors, which highlight the therapeutic virtues of extracts from American mangrove plants.
In-vitro Anti-diabetic and Antioxidant Efficacy of Methanolic Extract of Encephalartos ferox leaves
TLDR
It is apparent that E. ferox extract could serve as scaffold for diabetic therapy as it significantly inhibited α-glucosidase and pancreatic lipase in a dose dependent fashion and effectively reduced intestinal glucose absorption.
Enzymes inhibitors from natural sources with antidiabetic activity: A review
TLDR
This review will provide very useful material to enhance the efficiency of rational antidiabetic drug design.
In vitro Antioxidant and Antidiabetic Potential of Crude Extracts from the Seed Coat and Fruit Pulp of Strychnos madagascariensis
TLDR
Despite the potency of antidiabetic drugs such as voglibose, miglitol, acarbose, their safety remains burdensome, their drugs are associated with unwanted side effects such as abnormal weight gain, headache, nausea, diarrhea and dizziness, hence the search for safer and cheaper alternative antidi diabetic agents from plant origin.
Effect of Thermal Treatments Resembling Cooking on In Vitro Anti-Diabetic and Antioxidant Activities of Five Common Indian Pulses
  • 2017
Pulses are consumed in India after cooking for their high contents of proteins and other beneficial bioactive as part of traditional diets. The present study dealt with five different types of
Synthesis, Characterisation, Molecular Docking, Anti-microbial and Anti-diabetic Screening of Substituted 4-indolylphenyl-6-arylpyrimidine-2-imine Derivatives.
TLDR
In the in vitro anti-diabetic studies, compounds (11a, 11c, and 11g) confirm higher alpha-amylase and alpha-glucosidase inhibition activity and the entire compounds confirm very good antimicrobial activity towards the tested microorganisms.
Anti-Diabetic Potential of Plant-Based Pentacyclic Triterpene Derivatives: Progress Made to Improve Efficacy and Bioavailability
Diabetes mellitus (DM) results from the inability of the pancreas to produce sufficient insulin or weakened cellular response to the insulin produced, which leads to hyperglycemia. Current treatments
...
1
2
...

References

SHOWING 1-10 OF 17 REFERENCES
In-vitro α-amylase and α-glucosidase inhibitory activity of Adiantum caudatum Linn. and Celosia argentea Linn. extracts and fractions
TLDR
The results of the present study indicate that, fraction 2 of A. caudatum and fraction 4 of C. argentea, rich in flavonoids, are effective α- amylase and α- glucosidase inhibitors, which may be helpful to reduce the postprandial glucose levels.
Modes of Inhibition of α-Amylase and α-Glucosidase by Aqueous Extract of Morinda lucida Benth Leaf
TLDR
It can be concluded that aqueous extract of Morinda lucida exhibited the best inhibitory activity on the two enzymes studied and the presence of phytochemicals like flavonoids, saponins, and tannins may have contributed greatly to the inhibitoryactivity of the plant extract.
Inhibition of Alpha-glucosidase and Amylase by Luteolin, a Flavonoid
TLDR
Luteolin inhibited alpha-glucosidase by 36% at the concentration of 0.5 mg/ml and was stronger than acarbose, the most widely prescribed drug, in inhibitory potency, suggesting that it has the possibility to effectively suppress postprandial hyperglycemia in patients with non-insulin dependent diabetes mellitus.
α-Amylase inhibitors: a review of raw material and isolated compounds from plant source.
TLDR
Amongst the phyto-constituents that have been investigated, flavonoids are one of them that demonstrated the highest inhibitory activities with the potential of inhibition related to number of hydroxyl groups in the molecule of the compound.
Natural Products as α-Amylase and α-Glucosidase Inhibitors and their Hypoglycaemic Potential in the Treatment of Diabetes: An Update
TLDR
Recent data on plant extracts and isolated natural compounds that are being tested for their hypglycaemic activity are reviewed, ongoing research is highlighted, and the future persepctives are considered.
α-Glucosidase Inhibitory Profile of Catechins and Theaflavins
TLDR
It is demonstrated for the first time that TF-3-O-Gal can suppress glucose production from maltose through inhibition of AGH in the gut through the effects of catechins and theaflavins against alpha-glucosidase.
Inhibitory effects of five medicinal plants on ratalpha-glucosidase: Comparison with their effects on yeast alpha-glucosidase
The mammalian and yeast α-glucosidase inhibitory activities of Senna italica, Tinospora fragosa, Manilkara mochisia, Xanthocercis zambesiaca, Ozoroa cf. albicans, Peltophorum africanum, Cassia
The Inhibition of α-Amylase by Tea Polyphenols
TLDR
Among the samples tested, EC, EGC, and their isomers did not have significant effects on the activity of α-amylase, but all the other samples were potent inhibitors and the inhibitory effects were in the order of TF3>TF2A> TF2B>TFl>Cg> GCg > ECg > EGCg.
Soybean phenolic-rich extracts inhibit key-enzymes linked to type 2 diabetes (α-amylase and α-glucosidase) and hypertension (angiotensin I converting enzyme) in vitro.
  • A. O. Ademiluyi, G. Oboh
  • Chemistry, Medicine
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
  • 2013
Inhibitory effects of plant phenols on the activity of selected enzymes.
TLDR
In vitro experiments showed that the enzymatic activity of the derivatives of selected enzymes was adversely affected, and enzyme inhibition correlates well with the blocking of the mentioned amino acid side chains.
...
1
2
...