• Corpus ID: 89085324

IN-VITRO ALPHA-AMYLASE AND ALPHA-GLUCOSIDASE INHIBITION ACTIVITY OF UMBELLIFERONE AND BETA-IONONE ISOLATED FROM CORIANDRUM SATIVUM LINN.

@inproceedings{Rayar2016INVITROAA,
  title={IN-VITRO ALPHA-AMYLASE AND ALPHA-GLUCOSIDASE INHIBITION ACTIVITY OF UMBELLIFERONE AND BETA-IONONE ISOLATED FROM CORIANDRUM SATIVUM LINN.},
  author={Ayyasamy Rayar and Rajamanickam Manivannan},
  year={2016}
}
Aims: The objective of the present study was to provide an In‑Vitro evidence for the potential inhibitory activity of Ethanolic extract, Umbelliferone and β-Ionone on α‑amylase and α‑glucosidase enzymes. Materials and Methods: Differentconcentrations (0.1, 0.2, 0.3, 0.4, and 0.5 mg/ml) of Ethanolic extract, Umbelliferone and BetaIonone were subjected to α-amylase and α-glucosidase inhibitory assay. The absorbance was measuredat 540 and 405 nm using multiplate reader and the percentage of… 
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13 Citations

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Citation Type

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References

SHOWING 1-10 OF 17 REFERENCES
In-vitro α-amylase and α-glucosidase inhibitory activity of Adiantum caudatum Linn. and Celosia argentea Linn. extracts and fractions
TLDR
The results of the present study indicate that, fraction 2 of A. caudatum and fraction 4 of C. argentea, rich in flavonoids, are effective α- amylase and α- glucosidase inhibitors, which may be helpful to reduce the postprandial glucose levels.
Modes of Inhibition of α-Amylase and α-Glucosidase by Aqueous Extract of Morinda lucida Benth Leaf
TLDR
It can be concluded that aqueous extract of Morinda lucida exhibited the best inhibitory activity on the two enzymes studied and the presence of phytochemicals like flavonoids, saponins, and tannins may have contributed greatly to the inhibitoryactivity of the plant extract.
Inhibition of Alpha-glucosidase and Amylase by Luteolin, a Flavonoid
TLDR
Luteolin inhibited alpha-glucosidase by 36% at the concentration of 0.5 mg/ml and was stronger than acarbose, the most widely prescribed drug, in inhibitory potency, suggesting that it has the possibility to effectively suppress postprandial hyperglycemia in patients with non-insulin dependent diabetes mellitus.
α-Amylase inhibitors: a review of raw material and isolated compounds from plant source.
TLDR
Amongst the phyto-constituents that have been investigated, flavonoids are one of them that demonstrated the highest inhibitory activities with the potential of inhibition related to number of hydroxyl groups in the molecule of the compound.
Natural Products as α-Amylase and α-Glucosidase Inhibitors and their Hypoglycaemic Potential in the Treatment of Diabetes: An Update
TLDR
Recent data on plant extracts and isolated natural compounds that are being tested for their hypglycaemic activity are reviewed, ongoing research is highlighted, and the future persepctives are considered.
α-Glucosidase Inhibitory Profile of Catechins and Theaflavins
TLDR
It is demonstrated for the first time that TF-3-O-Gal can suppress glucose production from maltose through inhibition of AGH in the gut through the effects of catechins and theaflavins against alpha-glucosidase.
Inhibitory effects of five medicinal plants on ratalpha-glucosidase: Comparison with their effects on yeast alpha-glucosidase
The mammalian and yeast α-glucosidase inhibitory activities of Senna italica, Tinospora fragosa, Manilkara mochisia, Xanthocercis zambesiaca, Ozoroa cf. albicans, Peltophorum africanum, Cassia…
The Inhibition of α-Amylase by Tea Polyphenols
TLDR
Among the samples tested, EC, EGC, and their isomers did not have significant effects on the activity of α-amylase, but all the other samples were potent inhibitors and the inhibitory effects were in the order of TF3>TF2A> TF2B>TFl>Cg> GCg > ECg > EGCg.
Soybean phenolic-rich extracts inhibit key-enzymes linked to type 2 diabetes (α-amylase and α-glucosidase) and hypertension (angiotensin I converting enzyme) in vitro.
  • A. O. Ademiluyi, G. Oboh
  • Chemistry, Medicine
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
  • 2013
Inhibitory effects of plant phenols on the activity of selected enzymes.
TLDR
In vitro experiments showed that the enzymatic activity of the derivatives of selected enzymes was adversely affected, and enzyme inhibition correlates well with the blocking of the mentioned amino acid side chains.
...
1
2
...