• Corpus ID: 78177950

IN DEBATE: THE PRIMARY CAUSE OF TYPE 1 DIABETES

@inproceedings{IonescuTirgoviste2014INDT,
  title={IN DEBATE: THE PRIMARY CAUSE OF TYPE 1 DIABETES},
  author={Constantin Ionescu-Tirgoviste and Cristian Guja and Paul A. Gagniuc and Carol Davila and N. C. Paulescu},
  year={2014}
}
Diabetes mellitus is a huge syndrome manifested by many phenotypes, each having some pathogenic particularities. Despite this large heterogeneity, the unitary character keeping them together is supported by the same “sine qua non” condition for all, which is the decompensation of blood glucose regulation. This is induced by a decrease in β-cell mass/function. According to the autoimmune or non-autoimmune mechanism in the β-cell loss, the age of onset and the pre-diagnostic period could be… 

What is Before the Autoimmune Seroconversion in Type 1 Diabetes

Earlier stages of diabetes which silently operate before the detection of the first islet autoantibodies (mainly proinsulin/insulin antibodies) which strangely was omitted in the new mentioned reclassification of preclinical stages of type 1 diabetes.

THE FIRST DIABETOGENIC MOVES

The hypothesis is that the trigger of autoimmunity is represented in fact by the dysfunctional beta cells, the number of these cells and the magnitude of their secretory defect representing the key element differentiating the cases that will evolve rapidly towards complete beta cell loss and clinically overt diabetes, respectively those with “latent” and many times asymptomatic evolution even for decades.

PROTECTIVE ACTION OF NERVE GROWTH FACTOR (NGF) ON DEGENERATING RETINAL CELLS: NGF MEDIATES THE RESCUE EFFECT OF ADYPOCYTES?

  • 2016

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