IMPROVEMENT OF DISSOLUTION RATE OF VALSARTAN BY SOLID DISPERSION SYSTEM USING D(−) MANNITOL

@article{Zaini2017IMPROVEMENTOD,
  title={IMPROVEMENT OF DISSOLUTION RATE OF VALSARTAN BY SOLID DISPERSION SYSTEM USING D(−) MANNITOL},
  author={E. Zaini and S. Umar and N. Nurhidayah},
  journal={Asian Journal of Pharmaceutical and Clinical Research},
  year={2017},
  volume={10},
  pages={288-290}
}
  • E. Zaini, S. Umar, N. Nurhidayah
  • Published 2017
  • Materials Science
  • Asian Journal of Pharmaceutical and Clinical Research
  • ABSTRACT Objective: To improve dissolution rate of valsartan from solid dispersion system of valsartan and D(−) mannitol using co-grinding approach. Methods: Valsartan solid dispersion with different ratio of D(−) mannitol (1:1; 1:3 and 1: 5) were prepared by co-grinding method. Solid state characterization of the solid dispersion system was evaluated in term of crystallographic properties (powder X-ray diffraction), thermal behavior (differential scanning calorimetry [DSC]) and morphology… CONTINUE READING
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    SHOWING 1-10 OF 16 REFERENCES
    Physicochemical characterization and in vitro dissolution studies of solid dispersions of ketoprofen with PVP K30 and d-mannitol.
    • 69
    Physical properties and dissolution behaviour of nifedipine/mannitol solid dispersions prepared by hot melt method.
    • 100
    Preparation and characterization of solid dispersion freeze-dried efavirenz – polyvinylpyrrolidone K-30
    • 10
    Preparation of a solid dispersion of felodipine using a solvent wetting method.
    • 167
    Uniform nano-sized valsartan for dissolution and bioavailability enhancement: influence of particle size and crystalline state.
    • 31
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