IMPROVED SYNTHESIS OF MIRTAZAPINE

@article{Rao2007IMPROVEDSO,
  title={IMPROVED SYNTHESIS OF MIRTAZAPINE},
  author={D. S. Srinivasa Rao and R. Dandala and V. K. Handa and M. Sivakumaran and A. V. Raghava Reddy and A. Naidu},
  journal={Organic Preparations and Procedures International},
  year={2007},
  volume={39},
  pages={399 - 402}
}
Mirtazapine (6) has a tetracyclic chemical structure and belongs to the piperazinoazepine group of compounds with anti-depressant therapeutic effects. Mirtazapine is a racemate consisting of two pharmacologically active enantiomers, both of which contribute to the therapeutic effect.'J Three methods have been reported in the patent literature to prepare mir taz~p ine .~ -~ The most studied synthesis of mirtazapine3 (Scheme I ) has some disadvantages in each stage, such as the need for column… Expand
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