IMPALA: matching a protein sequence against a collection of PSI-BLAST-constructed position-specific score matrices

@article{Schffer1999IMPALAMA,
  title={IMPALA: matching a protein sequence against a collection of PSI-BLAST-constructed position-specific score matrices},
  author={Alejandro A. Sch{\"a}ffer and Yuri I. Wolf and Chris Paul Ponting and Eugene V. Koonin and L. Aravind and Stephen F. Altschul},
  journal={Bioinformatics},
  year={1999},
  volume={15 12},
  pages={1000-11}
}
MOTIVATION Many studies have shown that database searches using position-specific score matrices (PSSMs) or profiles as queries are more effective at identifying distant protein relationships than are searches that use simple sequences as queries. One popular program for constructing a PSSM and comparing it with a database of sequences is Position-Specific Iterated BLAST (PSI-BLAST). RESULTS This paper describes a new software package, IMPALA, designed for the complementary procedure of… CONTINUE READING
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