Corpus ID: 49524756

IMPACT OF SNP MUTATIONS ON THE STRUCTURAL AND FUNCTIONAL BEHAVIOUR OF CD 44 ASSOCIATED WITH ORAL CANCER

@inproceedings{Krishnaveni2018IMPACTOS,
  title={IMPACT OF SNP MUTATIONS ON THE STRUCTURAL AND FUNCTIONAL BEHAVIOUR OF CD 44 ASSOCIATED WITH ORAL CANCER},
  author={M. Krishnaveni and S. H. Basha},
  year={2018}
}
Oral cancer is a most prevalent cancer worldwide. Natural products are promising resource nowadays in research. Hence, Quinine was selected for the present study. CD44, a trans-membrane glycoprotein is a main hyaluronic acid(HA)binding receptor, expressed in cells, exhibits high affinity towards HA, increasing tumorigenesis. Altered CD44 glucosylation site, affects binding. Hence, computational modelling, simulation approach is applied to understand the effect of variants on the overall… CONTINUE READING

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