• Corpus ID: 49524756

IMPACT OF SNP MUTATIONS ON THE STRUCTURAL AND FUNCTIONAL BEHAVIOUR OF CD 44 ASSOCIATED WITH ORAL CANCER

@inproceedings{Krishnaveni2018IMPACTOS,
  title={IMPACT OF SNP MUTATIONS ON THE STRUCTURAL AND FUNCTIONAL BEHAVIOUR OF CD 44 ASSOCIATED WITH ORAL CANCER},
  author={Marimuthu Krishnaveni and Syed Hussain Basha},
  year={2018}
}
Oral cancer is a most prevalent cancer worldwide. Natural products are promising resource nowadays in research. Hence, Quinine was selected for the present study. CD44, a trans-membrane glycoprotein is a main hyaluronic acid(HA)binding receptor, expressed in cells, exhibits high affinity towards HA, increasing tumorigenesis. Altered CD44 glucosylation site, affects binding. Hence, computational modelling, simulation approach is applied to understand the effect of variants on the overall… 

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TLDR
The results raise the hypothesis of using CD44v6 as a marker of early invasive intramucosal carcinoma in HDGCCDH1 mutation carriers that lack CDH1 expression in their tumors.

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The results suggest that gene–environment interactions between the CD44 polymorphisms and betel quid chewing and tobacco smoking increase the susceptibility to oral cancer development.

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TLDR
The data of this study suggest that CD44v6 might be an independent prognostic factor in NSCLC and give another evidence of diverse role of CD44 in the differentiation and progression of non-small cell lung carcinomas and neuroendocrine carcinomas of the lung.

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TLDR
This review focuses primarily on experiments in which CD44 constructs are transfected into cells whose function is then assayed, showing that hyaluronan binding by CD44 is regulated by the cells in which it is expressed, and that at least part of this regulation is determined by cell specific posttranslational modifications, especially N-glycosylation of CD44 itself.

Characterization of the expression of variant and standard CD44 in prostate cancer cells: Identification of the possible molecular mechanism of CD44/MMP9 complex formation on the cell surface

TLDR
It is concluded that surface expression of CD44 and activation of MMP9 on the cell surface are interdependent.

Anti-angiogenesis property by Quercetin compound targeting VEGFR2 elucidated in a computational approach

TLDR
Quercetin compound demonstrated out ruling properties and interactions when compared the results with the VEGFR2 co-crystallized ligand AAZ, of high value for further designing potent target specific anti-angiogenesis drug.

Molecular docking and dynamic simulation studies evidenced plausible immunotherapeutic anticancer property by Withaferin A targeting indoleamine 2,3-dioxygenase

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An attempt to explore the potential of WA in attenuating IDO for immunotherapeutic tumor arresting activity and to elucidate the underlying mode of action in a computational approach strongly suggest WA as a valuable small ligand molecule with strong binding affinity toward IDO.

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A pivotal role of CXCR4, HER2 and CD44 expression as a prognostic factor of malignant human osteosarcoma is suggested, with a significant trend for a higher frequency of the expression of the three biomarkers in high-grade compared to low-grade osteosARcoma.