IMPACT, a Protein Preferentially Expressed in the Mouse Brain, Binds GCN1 and Inhibits GCN2 Activation*

@article{Pereira2005IMPACTAP,
  title={IMPACT, a Protein Preferentially Expressed in the Mouse Brain, Binds GCN1 and Inhibits GCN2 Activation*},
  author={C. Pereira and E. Sattlegger and H. Jiang and B. Longo and Carolina B. Jaqueta and A. Hinnebusch and R. Wek and L. Mello and B. Castilho},
  journal={Journal of Biological Chemistry},
  year={2005},
  volume={280},
  pages={28316 - 28323}
}
Translational control directed by the eukaryotic translation initiation factor 2 α-subunit (eIF2α) kinase GCN2 is important for coordinating gene expression programs in response to nutritional deprivation. The GCN2 stress response, conserved from yeast to mammals, is critical for resistance to nutritional deficiencies and for the control of feeding behaviors in rodents. The mouse protein IMPACT has sequence similarities to the yeast YIH1 protein, an inhibitor of GCN2. YIH1 competes with GCN2… Expand
Keeping the eIF2 alpha kinase Gcn2 in check.
Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.
Distribution of the protein IMPACT, an inhibitor of GCN2, in the mouse, rat, and marmoset brain
Gcn1 and Actin Binding to Yih1
Perturbations in actin dynamics reconfigure protein complexes that modulate GCN2 activity and promote an eIF2 response
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References

SHOWING 1-10 OF 35 REFERENCES
Glucose Limitation Induces GCN4Translation by Activation of Gcn2 Protein Kinase
The GCN2 eIF2α Kinase Is Required for Adaptation to Amino Acid Deprivation in Mice
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