IMP2/p62 induces genomic instability and an aggressive hepatocellular carcinoma phenotype

@article{Kessler2015IMP2p62IG,
  title={IMP2/p62 induces genomic instability and an aggressive hepatocellular carcinoma phenotype},
  author={Sonja M Kessler and Stephan Laggai and Ahmad Barghash and Christina S. Schultheiss and Eva Lederer and Monika Artl and Volkhard Helms and Johannes Haybaeck and Alexandra K Kiemer},
  journal={Cell Death and Disease},
  year={2015},
  volume={6},
  pages={e1894-}
}
Hepatocellular carcinoma (HCC) represents the third leading cause of cancer-related deaths and commonly develops in inflammatory environments. The IGF2 mRNA-binding protein IMP2-2/IGF2BP2-2/p62 was originally identified as an autoantigen in HCC. Aim of this study was to investigate a potential pathophysiological role of p62 in hepatocarcinogenesis. Human HCC tissue showed overexpression of IMP2, which strongly correlated with the fetal markers AFP and DLK1/Pref-1/FA-1 and was particularly… CONTINUE READING
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