IMMUNOLOGICAL STUDIES ON A C POLYSACCHARIDE COMPLEX OF GROUP A STREPTOCOCCI HAVING A DIRECT TOXIC EFFECT ON CONNECTIVE TISSUE

@article{Schwab1960IMMUNOLOGICALSO,
  title={IMMUNOLOGICAL STUDIES ON A C POLYSACCHARIDE COMPLEX OF GROUP A STREPTOCOCCI HAVING A DIRECT TOXIC EFFECT ON CONNECTIVE TISSUE},
  author={John H. Schwab and William James Cromartie},
  journal={The Journal of Experimental Medicine},
  year={1960},
  volume={111},
  pages={295 - 307}
}
A macromolecular complex of C polysaccharide and peptide derived from Group A streptococcal cells produces a multinodular, remittent, and intermittent lesion of dermal connective tissue following a single intradermal injection. This lesion is greatly modified, both in the gross and microscopically, in rabbits hyperimmunized with a Group A streptococcal vaccine. The immune serum, absorbed to yield only antibodies against C polysaccharide as indicated by agar diffusion techniques, will… CONTINUE READING

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