• Corpus ID: 28413214

IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS. I. PROPERTIES OF AN ANTIGEN IN CERTAIN STRAINS OF GROUP A STREPTOCOCCI EXHIBITING AN IMMUNOLOGIC CROSS-REACTION WITH HUMAN HEART TISSUE.

@article{Kaplan1963IMMUNOLOGICRO,
  title={IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS. I. PROPERTIES OF AN ANTIGEN IN CERTAIN STRAINS OF GROUP A STREPTOCOCCI EXHIBITING AN IMMUNOLOGIC CROSS-REACTION WITH HUMAN HEART TISSUE.},
  author={Melvin H. Kaplan},
  journal={Journal of immunology},
  year={1963},
  volume={90},
  pages={
          595-606
        }
}
  • M. H. Kaplan
  • Published 1 April 1963
  • Medicine, Biology
  • Journal of immunology
Summary Antisera prepared in rabbits against cell walls or M protein preparations of a group A type 5 strain of streptococcus have been found reactive by immunofluorescence and complement fixation with human heart tissue. The reactant in heart tissue was localized to cardiac myofibers of all heart specimens tested and in smooth muscle elements of vessel walls and endocardium of a proportion of heart specimens tested. Rheumatic and nonrheumatic hearts showed comparable reactivity. The reactant… 
IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS
Further evidence of a cross-reactive relationship between a cell wall antigen of certain Group A streptococcal strains and mammalian heart tissue is provided by the demonstration that goat antisera
IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS
TLDR
Sera from patients with recent streptococcal infection or non-suppurative sequelae exhibit with variable frequency a precipitin reaction in agar gel with a partially purified strePTococcal antigen, providing evidence that induction of cross-reactive autoantibody to heart in certain individuals is associated with streptitiscal infection.
Group a streptococcal antigens cross-reactive with myocardium. Purification of heart-reactive antibody and isolation and characterization of the streptococcal antigen
TLDR
To isolate and purifying the antigen from the group A streptococcus cross-reactive with sarcolemmal sheaths of cardiac myofibers, it became necessary to purify the HRA from rheumatic fever patients’ sera.
Study of heart-reactive antibody in antisera and hybridoma culture fluids against group A streptococci
TLDR
The ELISA was found to be an effective method for the detection of heart-reactive antibodies produced by murine hybridomas that were producing antibody to group A streptococci.
Antigens in Streptococcus mutans Cross Reactive with Human Heart Muscle
TLDR
The necessity for testing any future caries vaccine containing fractions of S mutans for the presence of this cross-reactive antigen to avoid a possible autoimmunization is dictated.
Binding of streptococcal antigens to muscle tissue in vitro
TLDR
Tissue-bound bacterial antigens were detected with homologous rabbit antisera with both indirect immunofluorescence tests and an indirect radioimmunoassay andSerological cross-reactivity was observed between the tissue-binding factors of S. pyogenes and S. mutans cells but not between the bacteria and muscle tissue.
AN IMMUNOLOGICAL RELATIONSHIP BETWEEN THE GROUP A STREPTOCOCCUS AND MAMMALIAN MUSCLE
By means of the immunofluorescent staining technique, antisera to a wide variety of serological types of Group A and A variant streptococci were found to contain an antibody which reacted with
Protective antigenic determinant of streptococcal M protein shared with sarcolemmal membrane protein of human heart
TLDR
Purified heart-reactive antibodies eluted from sarcolemmal membranes opsonized both types 5 and 19 streptococci, indicating that the heart cross-re active determinant of type 5 M protein is cross-protective.
Cross-Reactive Antigens of Group A Streptococci
TLDR
Evidence is provided about the identification and analysis of the cross-reactive antigens of the group A streptococcus and immune responses to N-acetyl-β-d-glucosamine, dominant epitope of group a polysaccharide, in the pathogenesis of rheumatic heart disease and sydenham chorea in acute rhematic fever.
Evidence for an immunological relationship between Streptococcus mutans and human cardiac tissue
TLDR
The hypothesis that immunization with S. mutans can induce autoimmune reactions is supported and antigens must be selected with caution before formulating any dental caries vaccine is indicated.
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References

SHOWING 1-10 OF 15 REFERENCES
IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS II. CROSS-REACTION OF ANTISERA TO MAMMALIAN HEART TISSUE WITH A CELL WALL CONSTITUENT OF CERTAIN STRAINS OF GROUP A STREPTOCOCCI
Further evidence of a cross-reactive relationship between a cell wall antigen of certain Group A streptococcal strains and mammalian heart tissue is provided by the demonstration that goat antisera
Immunologic studies of heart tissue. V. Antigens related to heart tissue revealed by cross-reaction of rabbit antisera to heterologous heart.
TLDR
Injection of rabbits with whole homogenates of heterologous heart from beef or rat, incorporated in aluminum hydoxide gel adjuvant, induced antibodies strongly reactive with saline extracts of normal rabbit heart by precipitation and complement-fixation tests, consistent with origin of the above antigen or antigens from sarcoplasmic reticulin or mitochondria.
Immunologic studies of heart tissue. IV. Serologic reactions with human heart tissue as revealed by immunofluorescent methods: isoimmune, Wassermann, and autoimmune reactions.
TLDR
Serologic reactions with homologous or autologous heart were observed particularly frequently with sera from rheumatic patients approximately 2 weeks following cardiac surgery, as well as in some non-rheumatic Patients following cardiac or thoracic surgery or acute myocardial infarction.
THE CELLULAR ANTIGENS OF GROUP A STREPTOCOCCI; IMMUNOELECTROPHORETIC STUDIES OF THE C, M, T, PGP, E4, F, AND E ANTIGENS OF SEROTYPE 17 STREPTOCOCCI.
TLDR
It is made here that E is a part of the M molecule, acquiring independent electrophoretic mobility when separated from the rest of theM molecule by acid hydrolysis and carrying an antigenic determinant serologically distinct from the determinant on the restof the M molecules.
PREPARATION AND PROPERTIES OF TYPE-SPECIFIC M ANTIGEN ISOLATED FROM A GROUP A, TYPE 1 HEMOLYTIC STREPTOCOCCUS
Type-specific M antigen was extracted by heating type 1 group A streptococci at pH 2 in a boiling water bath. The protein was then purified by digestion with a preparation of crystalline ribonuclease
Studies on L forms and protoplasts of group A streptococci. II. Chemical and immunological properties of the cell membrane.
  • E. Freimer
  • Biology, Medicine
    The Journal of experimental medicine
  • 1963
TLDR
Intact bacterial membranes have been isolated from protoplasts prepared from Group A streptococci by a cell wall-dissolving enzyme andCapillary precipitin tests and analysis by microdiffusion have demonstrated that the membrane contains antigens distinct from those of the cell wall and from the cytoplasm which it envelops.
IMMUNOLOGIC STUDIES OF HEART TISSUE III. OCCURRENCE OF BOUND GAMMA GLOBULIN IN AURICULAR APPENDAGES FROM RHEUMATIC HEARTS. RELATIONSHIP TO CERTAIN HISTOPATHOLOGIC FEATURES OF RHEUMATIC HEART DISEASE
TLDR
It is suggested that deposition of gamma globulin and the eosinophilic alteration associated with such deposition are related to certain of the pathologic changes of rheumatic heart disease.
PERSISTENCE OF TYPE-SPECIFIC ANTIBODIES IN MAN FOLLOWING INFECTION WITH GROUP A STREPTOCOCCI
  • R. Lancefield
  • Medicine, Biology
    The Journal of experimental medicine
  • 1959
TLDR
Two biological methods for estimating the amount of M antigen produced by Group A streptococci are described and the assay methods for M antigen are of value for other experimental purposes.
STUDIES ON STREPTOCOCCUS PYOGENES
  • H. D. Slade
  • Biology, Chemistry
    The Journal of general physiology
  • 1957
TLDR
Electron microscopic observations of Streptococcus pyogenes treated with trypsin and cetyltrimethylammonium bromide are presented and normal cells were shown to possess the ability to fluoresce in the presence of a dye.
Cross-reactions in the Ouchterlony plant: analysis of native and halogenated bovine serum albumins.
TLDR
It was concluded that the basic precipitate patterns described by Ouchterlony do not always indicate immunologic identity, partial identity, or nonidentity; these patterns can be considerably modified by changes in the relative concentrations of the immune systems.
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