IMMUNOGLOBULIN PURIFICATION BY AFFINITY CHROMATOGRAPHY USING PROTEIN A MIMETIC LIGANDS PREPARED BY COMBINATORIAL CHEMICAL SYNTHESIS

@article{Kabir2002IMMUNOGLOBULINPB,
  title={IMMUNOGLOBULIN PURIFICATION BY AFFINITY CHROMATOGRAPHY USING PROTEIN A MIMETIC LIGANDS PREPARED BY COMBINATORIAL CHEMICAL SYNTHESIS},
  author={S. Kabir},
  journal={Immunological Investigations},
  year={2002},
  volume={31},
  pages={263 - 278}
}
  • S. Kabir
  • Published 2002
  • Medicine, Biology
  • Immunological Investigations
  • Affinity chromatography using protein A from Staphylococcus aureus as the ligand has been widely used for the isolation of immunoglobulin G (IgG) from various species. Since ligand leakage from the affinity support can occur, time consuming analytical controls are required to detect the presence of contaminants associated with the isolated IgG prior to its use for therapeutic purpose in humans. Besides, protein A is an expensive bacterial product, whose isolation involves complex and labor… CONTINUE READING
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