IMMUNOCYTOCHEMISTRY OF NEUROFIBRILLARY TANGLES IN DEMENTIA PUGILISTICA AND ALZHEIMER'S DISEASE: EVIDENCE FOR COMMON GENESIS

@article{Roberts1988IMMUNOCYTOCHEMISTRYON,
  title={IMMUNOCYTOCHEMISTRY OF NEUROFIBRILLARY TANGLES IN DEMENTIA PUGILISTICA AND ALZHEIMER'S DISEASE: EVIDENCE FOR COMMON GENESIS},
  author={G. W. Roberts},
  journal={The Lancet},
  year={1988},
  volume={332},
  pages={1456-1458}
}
A battery of antisera that specifically stained the tangles of Alzheimer's disease also stained the tangles in all of 8 cases of dementia pugilistica (punch-drunk syndrome). Since the paired helical filament antigens found in Alzheimer type neurofibrillary degeneration are present in the tangles of dementia pugilistica the pathogenesis of tangle formation in these conditions is likely to be the same; thus head injury may be a predisposing factor or environmental trigger for Alzheimer's disease. 
Neurofibrillary tangles in dementia pugilistica are ubiquitinated.
TLDR
Examining ubiquitin immunoreactivity in a unique collection of brains from 16 ex-boxers including 11 with dementia pugilistica found it to be a component of neurofibrillary tangles in Alzheimer's disease. Expand
Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer's disease cases
TLDR
The association cortex of brains from dementia pugilistica patients demonstrated an inverse NFT distribution as compared to Alzheimer's disease, suggesting that a more circumscribed population of cortical pyramidal neurons might be affected in dementia pugs encephalopathy than in Alzhiemer's disease. Expand
Tau Protein and Frontotemporal Dementias.
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The structures of tau filaments from Pick's disease and corticobasal degeneration, determined by electron cryo-microscopy, revealed the presence of specific tau folds in each disease, with no inter-individual variation. Expand
Post–traumatic Alzheimer's disease: preponderance of a single plaque type
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This work has shown that the brains of boxers with dementia pugilistica (punch drunk syndrome) contain large numbers of ‘diffuse’ p–protein immunoreactive plaques, which might be associated with trauma induced Alzheimer–like degeneration. Expand
Frontal cortex neuropathology in dementia pugilistica.
TLDR
Detailed clinical and neuropathological data are described about a 55-year-old retired boxer (ApoE3/4), who presented with executive dysfunction and behavioral impairments and TDP-43-positive pathology was observed. Expand
Neuronal cytoskeletal changes are an early consequence of repetitive head injury
TLDR
It appears that repetitive head injury in young adults is initially associated with neocortical NFT formation in the absence of Aβ deposition, and the distribution of the tau pathology suggests that the pathogenesis of cytoskeletal abnormalities may involve damage to blood vessels or perivascular elements. Expand
Chapter 16 Molecular pathology of head trauma: altered βAPP metabolism and the aetiology of Alzheimer's disease
TLDR
Screening of the amyloid precursor protein gene on chromosome 21, which gives rise to the β -amyloid protein found in plaques, has revealed a mutation in some AD families. Expand
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Dementia Pugilistica Revisited
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It is unclear from the literature whether retired boxers reach the inflection point that tends toward progressive neurodegeneration in the manner of Alzheimer’s disease due to boxing, and more recent neuropathological studies indicate subclinical and possibly static tauopathy in some athletes and non-athletes. Expand
Re-examination of ex-boxers' brains using immunohistochemistry with antibodies to amyloid β-protein and tau protein
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The present observations indicate that the cerebral pathology of dementia pugilistica is very similar to that of Alzheimer's disease and suggest that these two disorders share some common etiological and pathogenic mechanisms. Expand
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References

SHOWING 1-10 OF 11 REFERENCES
Posttraumatic premature Alzheimer's disease. Neuropathologic findings and pathogenetic considerations.
TLDR
Dementia pugilistica and rare cases of classic Alzheimer's disease following head injury suggest that trauma may also play a provocative role in neurofibrillary change. Expand
Neurofibrillary tangle formation in the nucleus basalis of meynert ipsilateral to a massive cerebral infarct
Two cases of massive cerebral infarct in the territory of the middle cerebral artery on one side of the brain are presented, in which many (Patient 1) or several (Patient 2) neurofibrillaryExpand
Alzheimer's disease: Immunoreactivity of neurofibrillary tangles with anti-neurofilament and anti-paired helical filament antibodies
TLDR
It is concluded that neurofibrillary tangles in Alzheimer's disease are heterogeneous as regards their filamentous content and contain both antigen cross-reacting with neurofilaments and antigens which are apparently unique to PHF and not shared with normal neurofilament proteins. Expand
A case-control study of dementia of the Alzheimer type.
TLDR
The only major difference between patients with dementia of the Alzheimer type and controls was a significantly greater occurrence of antecedent head trauma in the patients, consistent with the literature on posttraumatic dementia but its importance is presently unclear. Expand
Organic psychosyndromes due to boxing.
  • J. Johnson
  • Medicine
  • The British journal of psychiatry : the journal of mental science
  • 1969
TLDR
The neuro-psychiatric findings in 17 ex-boxers are reported, along with psychometric, EEG and AEG investigations, and an organic psychosyndrome was manifest in a chronic amnesic state, morbid jealousy reactions, psychosis and "explosive" personality disorder in varying combination in 14 cases. Expand
Alzheimer's disease: A study of epidemiological aspects
TLDR
There appeared to be no major premorbid demographic or clinical factors associated with this form of dementia, and there was evidence, however, of a genetic factor that was manifested in an excess of dementia and mental retardation in families of patients with Alzheimer's disease. Expand
Alzheimer's paired helical filaments share epitopes with neurofilament side arms.
TLDR
It is proposed that in tangle‐bearing neurons, neurofilaments are degraded by proteases and that it is fragments of the side arms which contribute to the composition of PHF. Expand
The aftermath of boxing.
TLDR
A characteristic pattern of cerebral change has been identified which appears not only to be a result of the boxing but also to underlie many features of the punch-drunk syndrome. Expand
Neurological Sequelae of Boxing
TLDR
It appears that EEG has a role in determining when a boxer will return to the ring, and is less of a diagnostic tool for evaluating the encephalopathy, as well as being a significant risk factor for the development of meningiomas. Expand
Long-term outcome after severe head injury.
TLDR
On the basis of age at injury, the worst state of neurological responsiveness, and the duration of posttraumatic amnesia, the outcome of head injury can be predicted reliably in most cases. Expand
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