IMMUNOCYTOCHEMISTRY OF NEUROFIBRILLARY TANGLES IN DEMENTIA PUGILISTICA AND ALZHEIMER'S DISEASE: EVIDENCE FOR COMMON GENESIS

@article{Roberts1988IMMUNOCYTOCHEMISTRYON,
  title={IMMUNOCYTOCHEMISTRY OF NEUROFIBRILLARY TANGLES IN DEMENTIA PUGILISTICA AND ALZHEIMER'S DISEASE: EVIDENCE FOR COMMON GENESIS},
  author={George Washington Roberts},
  journal={The Lancet},
  year={1988},
  volume={332},
  pages={1456-1458}
}
Neurofibrillary tangles in dementia pugilistica are ubiquitinated.
TLDR
Examining ubiquitin immunoreactivity in a unique collection of brains from 16 ex-boxers including 11 with dementia pugilistica found it to be a component of neurofibrillary tangles in Alzheimer's disease.
Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer's disease cases
TLDR
The association cortex of brains from dementia pugilistica patients demonstrated an inverse NFT distribution as compared to Alzheimer's disease, suggesting that a more circumscribed population of cortical pyramidal neurons might be affected in dementia pugs encephalopathy than in Alzhiemer's disease.
Tau Protein and Frontotemporal Dementias.
TLDR
The structures of tau filaments from Pick's disease and corticobasal degeneration, determined by electron cryo-microscopy, revealed the presence of specific tau folds in each disease, with no inter-individual variation.
Rapid Communication Neurofibrillary Tangles in Some Cases of Dementia Pugilistica Share Antigens with Amyloid fl-Protein of Alzheimer's Disease
TLDR
Formalin-fixed, paraffin-embedded temporal lobe sections from eight former boxers' brains were ex-amined using an immunohistochemical method with antibodies to amyloid f3 protein to emphasize the many similarities in pathology between this condition and Alzbeimer's disease.
Post–traumatic Alzheimer's disease: preponderance of a single plaque type
TLDR
This work has shown that the brains of boxers with dementia pugilistica (punch drunk syndrome) contain large numbers of ‘diffuse’ p–protein immunoreactive plaques, which might be associated with trauma induced Alzheimer–like degeneration.
Frontal cortex neuropathology in dementia pugilistica.
TLDR
Detailed clinical and neuropathological data are described about a 55-year-old retired boxer (ApoE3/4), who presented with executive dysfunction and behavioral impairments and TDP-43-positive pathology was observed.
Neuronal cytoskeletal changes are an early consequence of repetitive head injury
TLDR
It appears that repetitive head injury in young adults is initially associated with neocortical NFT formation in the absence of Aβ deposition, and the distribution of the tau pathology suggests that the pathogenesis of cytoskeletal abnormalities may involve damage to blood vessels or perivascular elements.
Ontstekingsmechanismen in de pathogenese van de ziekte van Alzheimer
TLDR
Although the results of these studies suggest a beneficial effect of therapy with anti-inflammatory agents, further study is warranted to gain more insight into the fundamental aspects of such treatment as well as to develop specific drugs that have little side-effects.
Dementia Pugilistica Revisited
TLDR
It is unclear from the literature whether retired boxers reach the inflection point that tends toward progressive neurodegeneration in the manner of Alzheimer’s disease due to boxing, and more recent neuropathological studies indicate subclinical and possibly static tauopathy in some athletes and non-athletes.
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References

SHOWING 1-10 OF 11 REFERENCES
Neurofibrillary tangle formation in the nucleus basalis of meynert ipsilateral to a massive cerebral infarct
Two cases of massive cerebral infarct in the territory of the middle cerebral artery on one side of the brain are presented, in which many (Patient 1) or several (Patient 2) neurofibrillary
A case-control study of dementia of the Alzheimer type.
TLDR
The only major difference between patients with dementia of the Alzheimer type and controls was a significantly greater occurrence of antecedent head trauma in the patients, consistent with the literature on posttraumatic dementia but its importance is presently unclear.
Alzheimer's disease: A study of epidemiological aspects
TLDR
There appeared to be no major premorbid demographic or clinical factors associated with this form of dementia, and there was evidence, however, of a genetic factor that was manifested in an excess of dementia and mental retardation in families of patients with Alzheimer's disease.
Alzheimer's paired helical filaments share epitopes with neurofilament side arms.
TLDR
It is proposed that in tangle‐bearing neurons, neurofilaments are degraded by proteases and that it is fragments of the side arms which contribute to the composition of PHF.
Organic Psychosyndromes due to Boxing
  • John Johnson
  • Psychology, Medicine
    British Journal of Psychiatry
  • 1969
TLDR
The “punch-drunk” syndrome of boxers was recognized by lay people many years before it received attention from the medical profession and Martland gave the first clinical description of its neurological and psychiatric features.
The aftermath of boxing.
TLDR
A characteristic pattern of cerebral change has been identified which appears not only to be a result of the boxing but also to underlie many features of the punch-drunk syndrome.
Neurological Sequelae of Boxing
TLDR
It appears that EEG has a role in determining when a boxer will return to the ring, and is less of a diagnostic tool for evaluating the encephalopathy, as well as being a significant risk factor for the development of meningiomas.
Long-term outcome after severe head injury.
TLDR
On the basis of age at injury, the worst state of neurological responsiveness, and the duration of posttraumatic amnesia, the outcome of head injury can be predicted reliably in most cases.
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