IMMUNOBIOLOGY CD95 engagement induces disseminated endothelial cell apoptosis in vivo: immunopathologic implications

Abstract

Fas (CD95) is a death receptor involved in apoptosis induction on engagement by Fas ligand (CD95L). Although CD95Lmediated apoptosis has been proposed as a pathogenic mechanism in a wide range of diseases, including graft-versushost disease, systemic CD95 engagement in mice by agonistic CD95-specific antibodies or by soluble multimeric CD95L (smCD95L… (More)

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