IMGT, a system and an ontology that bridge biological and computational spheres in bioinformatics

@article{Lefranc2008IMGTAS,
  title={IMGT, a system and an ontology that bridge biological and computational spheres in bioinformatics},
  author={Marie-Paule Lefranc and V{\'e}ronique Giudicelli and Laetitia Regnier and Patrice Duroux},
  journal={Briefings in bioinformatics},
  year={2008},
  volume={9 4},
  pages={
          263-75
        }
}
IMGT, the international ImMunoGeneTics information system (http://imgt.cines.fr), is the reference in immunogenetics and immunoinformatics. IMGT standardizes and manages the complex immunogenetic data that include the immunoglobulins (IG) or antibodies, the T cell receptors (TR), the major histocompatibility complex (MHC) and the related proteins of the immune system (RPI), which belong to the immunoglobulin superfamily (IgSF) and the MHC superfamily (MhcSF). The accuracy and consistency of… 

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References

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TLDR
The IMGT-ONTOLOGY allows scientists and clinicians to use, for the first time, identical terms with the same meaning in immunogenetics and provides a semantic repository that will improve interoperability between specialist and generalist databases.
Immunogenetics Sequence Annotation: the Strategy of IMGT based on IMGT-ONTOLOGY
TLDR
The strategy developed by IMGT, for the IG and TR nucleotide sequence annotation, involves two different approaches that depend on the nature of the sequences, genomic DNA (gDNA) or complementary DNA (cDNA).
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TLDR
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IMGT®, the international ImMunoGeneTics information system®
TLDR
IMGT, the international ImMunoGeneTics information system, was created in 1989 by Marie-Paule Lefranc, Laboratoire d'ImmunoGénétique Moléculaire LIGM at Montpellier, France, in order to standardize and manage the complexity of immunogenetics data.
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TLDR
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TLDR
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TLDR
The IMGT Scientific chart rules for the description of the IgSF (V and C types) and of the MhcSF (G type) domains are reviewed, based on the IMGT-ONTOLOGY axioms and concepts and are applicable for the sequence and structure analysis.
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