ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression

@article{Lahsnig2009ILEIRO,
  title={ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression},
  author={Christian Lahsnig and Mario Mikula and Michaela Petz and Gudrun Zulehner and Doris Schneller and F van Zijl and Heidemarie Huber and Anna Csisz{\'a}r and Hartmut Beug and Wolfgang Mikulits},
  journal={Oncogene},
  year={2009},
  volume={28},
  pages={638-650}
}
In human hepatocellular carcinoma (HCC), epithelial to mesenchymal transition (EMT) correlates with aggressiveness of tumors and poor survival. We employed a model of EMT based on immortalized p19ARF null hepatocytes (MIM), which display tumor growth upon expression of oncogenic Ras and undergo EMT through the synergism of Ras and transforming growth factor (TGF)-β. Here, we show that the interleukin-related protein interleukin-like EMT inducer (ILEI), a novel EMT-, tumor- and metastasis… CONTINUE READING

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