IL4 production and increased CD30 expression by a unique CD8+ T-cell subset in B-cell chronic lymphocytic leukaemia.

@article{Totero1999IL4PA,
  title={IL4 production and increased CD30 expression by a unique CD8+ T-cell subset in B-cell chronic lymphocytic leukaemia.},
  author={Daniela de Totero and Gigliola Reato and F R Mauro and Alessandro Cignetti and Silvano Ferrini and Anna Rita Guarini and Marco Gobbi and Carlo Enrico Grossi and Robin Fo{\'a}},
  journal={British journal of haematology},
  year={1999},
  volume={104 3},
  pages={589-99}
}
Phenotypic and functional abnormalities within the residual non-B-cell compartment of B-cell chronic lymphocytic leukaemia (CLL) suggest an interaction between tumour cells and host immune effectors. To explore the possibility of a polarized Th1/Th2 response we have studied CD30 antigen expression and the pattern of cytokine production by purified CLL T cells. Activated T cells from CLL patients showed a significant increase in the expression of CD30 compared to normal controls. Accordingly… CONTINUE READING
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