IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C.

@article{Urban2010IL28BGI,
  title={IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C.},
  author={Thomas J. Urban and Alexander Thompson and Shelton S. Bradrick and Jacques Fellay and Detlef B Schuppan and Kenneth D. Cronin and Linda Hong and Alexander McKenzie and Keyur A. Patel and Kevin V. Shianna and John McHutchison and David K. Goldstein and Nezam H. Afdhal},
  journal={Hepatology},
  year={2010},
  volume={52 6},
  pages={1888-96}
}
UNLABELLED Genetic variation in the IL28B (interleukin 28B; interferon lambda 3) region has been associated with sustained virological response (SVR) rates in patients with chronic hepatitis C (CHC) who were treated with peginterferon-α and ribavirin. We hypothesized that IL28B polymorphism is associated with intrahepatic expression of interferon-stimulated genes (ISGs), known to influence treatment outcome. IL28B genotyping (rs12979860) and whole-genome RNA expression were performed using… CONTINUE READING
Highly Influential
This paper has highly influenced 15 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
189 Citations
29 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 189 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 29 references

Hepatic interferon - stimulated genes expression is associated with genetic variation in interleukin 28 B and the outcome of interferon therapy for chronic hepatitis C

  • M Honda, A Sakai, T Yamashita, Y Nakamoto, E Mizukoshi, Y Sakai
  • Gastroenterology
  • 2010

Similar Papers

Loading similar papers…