IL28B and the control of hepatitis C virus infection.

@article{Balagopal2010IL28BAT,
  title={IL28B and the control of hepatitis C virus infection.},
  author={Ashwin Balagopal and David L. Thomas and Chloe L Thio},
  journal={Gastroenterology},
  year={2010},
  volume={139 6},
  pages={
          1865-76
        }
}
Treatment-induced control and spontaneous clearance of hepatitis C virus (HCV) infection are affected by various host factors. Polymorphisms in the region of the gene IL28B are associated with HCV clearance, implicating the gene product, interferon (IFN)-λ3, in the immune response to HCV. Although it is not clear how the IL28B haplotype affects HCV clearance, IFN-λ3 up-regulates interferon-stimulated genes, similar to IFN-α and IFN-β but via a different receptor. There is also evidence that IFN… CONTINUE READING

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