IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin.

@article{Chakravorty2009IL1BPP,
  title={IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin.},
  author={Meenakshi Chakravorty and Dipanjana Datta De and Abhijit Choudhury and Susanta Roychoudhury},
  journal={The international journal of biochemistry & cell biology},
  year={2009},
  volume={41 7},
  pages={
          1502-10
        }
}
It is important to dissect the effect of the alternative alleles of a functional SNP on the entire biochemical pathway for the complete understanding of the mechanism of the manifestation of complex diseases. IL1B-511C>T and -31C>T promoter polymorphisms have been suggested as potential susceptibility loci for Helicobacter pylori associated gastroduodenal diseases. We report that altered expression of IL1B due to a specific polymorphism in its promoter modulates the expression of gastrin, an… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 51 REFERENCES

Regulation of the RelA (p65) transactivation

JM ’Shea, ND Perkins
  • domain. Biochem Soc Trans 2008;36:603–8
  • 2008

Regulationof theRelA ( p 65 ) transactivationdomain

JB atrone, SE Bish, DC Stein
  • Biochem Soc Trans
  • 2008