IL17A impairs blood–testis barrier integrity and induces testicular inflammation

@article{Prez2014IL17AIB,
  title={IL17A impairs blood–testis barrier integrity and induces testicular inflammation},
  author={Cecilia Valeria P{\'e}rez and Eliana Herminia Pellizzari and Selva Beatriz Cigorraga and Mar{\'i}a Noel Galardo and Munekazu Naito and Livia Lustig and Patricia Ver{\'o}nica Jacobo},
  journal={Cell and Tissue Research},
  year={2014},
  volume={358},
  pages={885-898}
}
Experimental autoimmune orchitis is a useful model for studying testicular inflammation and germ/immune cell interactions. Th17 cells and their hallmark cytokine IL17A were reported to be involved in the development of autoimmune orchitis. The aim of the present work is to investigate the pathogenic role of IL17A in rat testis. In vitro experiments were performed in order to analyze effects of IL17A on Sertoli cell tight junctions. The addition of IL17A to normal rat Sertoli cell cultures… CONTINUE READING