IL17A-Mediated Endothelial Breach Promotes Metastasis Formation.

Abstract

The role of the IL23/IL17A axis in tumor-immune interactions is a matter of controversy. Although some suggest that IL17A-producing T cells (TH17) can suppress tumor growth, others report that IL17A and IL23 accelerate tumor growth. Here, we systematically assessed the impact of IL17A-secreting lymphocytes in several murine models of tumor lung metastasis… (More)
DOI: 10.1158/2326-6066.CIR-15-0154

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