IL12/23 p40 inhibition ameliorates Alzheimer's disease-associated neuropathology and spatial memory in SAMP8 mice.

@article{Tan2014IL1223PI,
  title={IL12/23 p40 inhibition ameliorates Alzheimer's disease-associated neuropathology and spatial memory in SAMP8 mice.},
  author={M S Tan and Jintai Yu and Teng Jiang and Xi-Chen Zhu and Hua-shi Guan and Lin Tan},
  journal={Journal of Alzheimer's disease : JAD},
  year={2014},
  volume={38 3},
  pages={633-46}
}
Progressively increased proinflammatory status is a major characteristic of the aging process and associated with age-related diseases such as Alzheimer's diseases (AD). However, the regulation and role of common proinflammatory cytokines, including interleukin-12 (IL-12) and IL-23, in the aged brain are still unclear. Using the senescence-accelerated mouse prone-8 (SAMP8) model, we screened the cerebral expression of IL-12/23 in 3-, 7-, and 11-month-old mice and observed that their levels in… CONTINUE READING
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